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Efficacy of risedronate administration in osteoporotic postmenopausal women affected by inflammatory bowel disease

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Abstract

Patients with inflammatory bowel disease (IBD) have frequently a bone mineral density (BMD) significantly lower than age-matched healthy subjects. The low BMD observed in IBD patients is related also to a higher incidence of bone fractures. In this prospective randomized study we evaluated the effect of 1-year risedronate administration on bone mass and turnover, and on vertebral fractures in osteoporotic postmenopausal women with IBD in remission. Ninety osteoporotic postmenopausal women were randomized to receive oral risedronate 35 mg/week (risedronate group) or placebo tablets (placebo group; one tab/week). The duration of treatment was 12 months. At entry and after treatment, lumbar spine and hip BMD, and serum osteocalcin (OC) and urinary deoxypyridinoline/creatinine ratio (DPD-Cr) levels were evaluated. Vertebral fractures were assessed from thoracic and lumbar lateral and anterior-posterior spinal radiographs taken at baseline, and from lateral spinal radiographs taken at the end of the study. At study entry, no difference between groups was also detected in BMD and in bone turnover markers. At the end of the study, lumbar spine, trochanter and femoral neck BMD was significantly ( p <0.05) higher in comparison with baseline in the risedronate group, whereas a significant ( p <0.05) decrease was observed in the placebo group. For the same visit, a significant ( p <0.05) difference in lumbar spine, trochanter and femoral neck BMD was detected between groups. After 12-month follow-up, serum OC and urinary DPD-Cr levels were significantly ( p <0.05) lower and higher in comparison with basal values in risedronate and placebo group, respectively. At the same time, a significant ( p <0.05) difference in serum OC and urinary DPD-Cr levels was observed between groups. Throughout the study, the incidence of vertebral fractures was significantly ( p <0.05) lower in the risedronate group than in the placebo group (12.5% vs 34.1%). The relative risk (RR) to develop a new vertebral fracture after 1 year of risedronate administration was of 0.36 (95% confidence interval, 0.14–0.85). In conclusion, risedronate administration is an effective anti-osteoporotic treatment in osteoporotic postmenopausal women with IBD in remission.

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Acknowledgements

No financial support was provided by any pharmaceutical company to realize the present research

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University “Magna Graecia” of Catanzaro, Catanzaro, Italy

    Stefano Palomba, Angela Falbo, Tiziana Russo & Fulvio Zullo

  2. Department of Molecular and Clinical Endocrinology and Oncology, University “Federico II” of Naples, Naples, Italy

    Francesco Orio Jr., Libuse Tauchmanovà & Annamaria Colao

  3. Department of Gastroenterology, University “Federico II” of Naples, Naples, Italy

    Francesco Manguso

  4. Department of Obstetrics and Gynecology, University “Federico II” of Naples, Naples, Italy

    Achille Tolino

  5. Department of Gastroenterology, University “Magna Graecia” of Catanzaro, Catanzaro, Italy

    Patrizia Doldo

  6. Department of Obstetrics and Gynecology, University of Messina, Messina, Italy

    Pasquale Mastrantonio

  7. Via E. Nicolardi 188, 80131, Naples, Italy

    Stefano Palomba

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  1. Stefano Palomba
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  2. Francesco Orio Jr.
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Correspondence to Stefano Palomba.

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Palomba, S., Orio, F., Manguso, F. et al. Efficacy of risedronate administration in osteoporotic postmenopausal women affected by inflammatory bowel disease. Osteoporos Int 16, 1141–1149 (2005). https://doi.org/10.1007/s00198-005-1927-z

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  • DOI: https://doi.org/10.1007/s00198-005-1927-z

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