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Consumption of a high calcium mineral water lowers biochemical indices of bone remodeling in postmenopausal women with low calcium intake

Osteoporosis International volume 16, pages 1203–1209 (2005)Cite this article

Abstract

Many postmenopausal women have a calcium intake far below the recommended amount and, in addition to attempting to improve their diet, need a calcium supplement. The aim of the study was to assess the effects of the consumption of a high calcium mineral water (HCaMW) on biochemical indices of bone remodeling in postmenopausal women with low Ca intake. A 6-month randomized double-blind placebo-controlled trial was designed to assess the effects of a daily consumption of 1 liter of a HCaMW (596 mg Ca/l) on serum parathyroid hormone (PTH) and biochemical markers of bone remodeling in postmenopausal women with a dietary Ca intake lower than 700 mg/day. The placebo group drank 1 liter of a mineral water with a low calcium content (10 mg/l). One hundred eighty healthy women were recruited (mean age: 70.1±4.0 years); 152 completed the 6-month trial. The changes from baseline of biochemical indices after 6 months consisted of a significant 14.1% decrease of serum PTH, osteocalcin (–8.6%), bone alkaline phosphatase (–11.5%), serum (–16.3%) and urine (–13.0%) type-1 collagen C-telopeptide in the HCaMW group compared to the placebo group, where all biochemical indices increased after 6 months. The additive effect of a small vitamin D supplement (400 iu/day) was also evaluated. In women receiving vitamin D in addition to HCaMW, the decrease in bone indices was not found to be greater than in women drinking only the HCaMW. A daily supplement of 596 mg of Ca through the consumption of 1 l of HCaMW was able to lower serum PTH and the indices of bone turnover in postmenopausal women with a low Ca intake. This could contribute to the repair of calcium deficiency and to the reduction of age-related bone loss in this population.

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Fig. 1 a, b, c, d

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Authors and Affiliations

  1. Faculty of Medicine RTH, Laennec Inserm Unit 403, rue G. Paradin, 69372, Lyon Cedex 08, France

    Pierre J. Meunier & Cecile Jenvrin

  2. INSERM Unit 403, Lyon, France

    Françoise Munoz

  3. Centre Evian pour l’Eau, Paris, France

    Viviane de la Gueronnière

  4. SYNARC, Lyon, France

    Patrick Garnero

  5. Centre Régional de Prévention des Institutions de Retraite, Lyon, France

    Michèle Menz

Authors
  1. Pierre J. Meunier
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  2. Cecile Jenvrin
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  3. Françoise Munoz
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  4. Viviane de la Gueronnière
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  5. Patrick Garnero
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  6. Michèle Menz
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Correspondence to Pierre J. Meunier.

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This study was supported by a grant from Evian.

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Meunier, P.J., Jenvrin, C., Munoz, F. et al. Consumption of a high calcium mineral water lowers biochemical indices of bone remodeling in postmenopausal women with low calcium intake. Osteoporos Int 16, 1203–1209 (2005). https://doi.org/10.1007/s00198-004-1828-6

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  • DOI: https://doi.org/10.1007/s00198-004-1828-6

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