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Geschlechtsbestimmung mit dem Amelogeninsystem

Kasuistische Betrachtung möglicher Fehlerquellen

Sex determination with the amelogenin system

Casuistic consideration of possible errors

Rechtsmedizin volume 24, pages 30–36 (2014)Cite this article

Zusammenfassung

Die Untersuchung des Amelogeninsystems in der forensischen Genetik dient der genotypischen Geschlechtszuordnung von Spurenproben und ermöglicht die einzige, gesetzlich zugelassene, phänotypische Information über eine gesuchte Person. Insofern kommt den Befunden der Amelogeninanalyse weitreichende Bedeutung in der Interpretation von forensischem Spurenmaterial zu. In den letzten Jahren wurden viele Mutationen in dem untersuchten Locus beschrieben. Bereits hieraus kann abgeleitet werden, dass das Amelogeninsystem anfällig für Fehlinterpretationen ist. Im Folgenden werden anhand von 2 Fällen aus der praktischen Arbeit, die einen ungewöhnlichen Amelogeninbefund aufwiesen, Besonderheiten und mögliche Fehlerquellen dieser Untersuchungsmethode aufgezeigt und diskutiert.

Abstract

The investigation oft the amelogenin locus in forensic genetics is used for genotypic sex determination from forensic traces and is the only legally accepted genetic investigation about the phenotype of a crime suspect. The information gained from the analysis of the amelogenin locus has important implications for the interpretation of forensic traces. Over the last few years a plethora of mutations have been described within the amelogenin locus so that this locus is prone to erroneous interpretation. This article describes two cases with an unusual amelogenin status and discusses possible sources of error.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. B. Balitzki, P.J. Laberke, L. Jegge, E. Kübler geben an, dass kein Interessenkonflikt besteht. Der Beitrag enthält keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Forensische Genetik, Gesundheitsdepartment, Gesundheitsschutz, Institut für Rechtsmedizin, Pestalozzistr. 22, 4056, Basel, Schweiz

    B. Balitzki, P.J. Laberke & L. Jegge

  2. Fachhochschule Nordwestschweiz, Hochschule für Life Sciences, Muttenz, Schweiz

    E. Kübler

Authors
  1. B. Balitzki
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  2. P.J. Laberke
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  3. L. Jegge
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  4. E. Kübler
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Correspondence to B. Balitzki.

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Balitzki, B., Laberke, P., Jegge, L. et al. Geschlechtsbestimmung mit dem Amelogeninsystem. Rechtsmedizin 24, 30–36 (2014). https://doi.org/10.1007/s00194-013-0931-4

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  • DOI: https://doi.org/10.1007/s00194-013-0931-4

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