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Microbiologist in the Clinic: Postmenopausal Woman with Chronic OAB and Positive Urine Culture

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Abstract

In this second episode of the Microbiologist in the Clinic series, clinicians and laboratory scientists share their perspectives about a 75-year-old woman who was diagnosed with asymptomatic bacteriuria based on positive urine cultures. The patient and her GP are concerned about this laboratory finding as the patient will become immunosuppressed with planned chemotherapy. The patient has had an overactive bladder (OAB) for approximately 20 years, with good control of her urinary urgency and frequency (no incontinence) with a stable dose of OAB medication. The challenges of this clinical presentation are discussed, with evidence for evaluation and treatment.

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Author information

Authors and Affiliations

  1. Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA

    Linda Brubaker

  2. Department of Renal Medicine, Division of Medicine, UCL, London, UK

    Harry Horsley

  3. Eastman Dental Institute, Department of Microbial Disease, UCL, London, UK

    Rajvinder Khasriya

  4. Department of Microbiology and Immunology, Loyola University, Chicago, IL, USA

    Alan J. Wolfe

Authors
  1. Linda Brubaker
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  2. Harry Horsley
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  3. Rajvinder Khasriya
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  4. Alan J. Wolfe
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Contributions

All authors contributed to conceptualization (as part of a 2021 IUGA workshop) and writing all drafts, in addition to review and editing.

Corresponding author

Correspondence to Linda Brubaker.

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Ethical approval

As no protected health information was included in this conversational commentary, no ethical approval was sought or required.

Conflicts of interest

L.B.: editorial stipends from JAMA and Up To Date; H.H.: no disclosures; H.K.: no disclosures; A.J.W.: advisory boards at Urobiome Therapeutics and Pathnostics and funding from NIH, Craig H. Neilsen Foundation, Pathnostics, and VB Tech.

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Handling Editor: Annette Kuhn

Editor in Chief: Kaven Baessler

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Brubaker, L., Horsley, H., Khasriya, R. et al. Microbiologist in the Clinic: Postmenopausal Woman with Chronic OAB and Positive Urine Culture. Int Urogynecol J (2024). https://doi.org/10.1007/s00192-024-05819-y

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  • DOI: https://doi.org/10.1007/s00192-024-05819-y

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