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Comparative study of two different rat models of stress urinary incontinence

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Abstract

Introduction and hypothesis

The purpose of this study was to compare the success rate and urodynamic characteristics of the rat model of stress Urinary incontinence established by ovariectomy at different times after vaginal dilation.

Methods

Eighty female rats were randomly divided into three groups: the control group (n = 20), model group A (n = 30), i.e., the animals received colpectasis and bilateral oophorectomy within 1 day; model group B (n = 30), i.e., the animals received bilateral oophorectomy 1 week after colpectasis. The sneeze test and urodynamics were tested.

Results

There was no significant difference between the model group A and the model group B (p > 0.05) in the sneeze test. The leak point pressure (LPP) of model groups A and B was lower than that of the control group (p < 0.05). The LPP value of model group A was lower than that of model group B (p < 0.05). There was no significant difference in maximum bladder capacity (MBC) between model group A and the control group (p > 0.05); the MBC value of model group B was lower than that of the control group and model group A (p < 0.05).

Conclusions

Models of stress urinary incontinence in rats can be successfully established by both modeling methods. In terms of LPP, model groups A and B had lower values than the control group, and model group A had lower values than model group B. In terms of MBC, there was no difference between model group A and the control group, and model group B had lower values than the control group and model group A.

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Acknowledgements

We thank Shanghai University of Traditional Chinese Medicine for the laboratory and the National Natural Science Foundation of China (NO.81774409) and Shanghai Municipal Health Commission (NO.201940011) for funding.

Funding

This work was supported by funding from the National Natural Science Foundation of China (nos. 81774409) and the Shanghai Municipal Health Commission (no. 201940011).

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Author notes

  1. Zhiyu Qu and Bingli Chen contributed equally to this work

Authors and Affiliations

  1. Acupuncture Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong New District, City, Shanghai, SH 21, China

    Zhiyu Qu, Bingli Chen, Mengyi Yang, Shuren Ming & Wenguang Hou

  2. LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China

    Yuelai Chen

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  1. Zhiyu Qu
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Contributions

Wenguang Hou, Yuelai Chen and Shuren Ming: project development; Zhiyu Qu and Bingli Chen: data collection, data analysis and manuscript writing, contributed equally to this work; Mengyi Yang: participated in animal experiments.

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Correspondence to Shuren Ming or Wenguang Hou.

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Qu, Z., Chen, B., Yang, M. et al. Comparative study of two different rat models of stress urinary incontinence. Int Urogynecol J 34, 2867–2872 (2023). https://doi.org/10.1007/s00192-023-05593-3

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  • DOI: https://doi.org/10.1007/s00192-023-05593-3

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