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Associations between metabolic syndrome and female stress urinary incontinence: a meta-analysis

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Abstract

Introduction and hypothesis

The objective was to identify the associations between metabolic syndrome (MS) and stress urinary incontinence (SUI) in women and to provide an evidence base for clinical practice.

Methods

A meta-analysis of cohort, case–control, and cross-sectional studies about the association between MS and SUI was performed using databases including PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBMdisc), Wanfang Database (WanFang Data), and VIP database (VIP). The time limit was from the commencement of each database to 1 November 2020. Two researchers independently screened literature, extracted data, and assessed the risk of bias. RevMan 5.3 software was used for statistical analysis. The dichotomous variables were presented as the risk ratio (odds ratio, OR) and 95% CI as the effect indicators.

Results

Six studies were included in the meta-analysis, with a total sample size of 3,678 cases. The results showed that the risk for SUI in women with MS was three times those without MS (OR = 3.41, 95% CI 2.01, 5.77, p <0.00001), and the difference was statistically significant. The results of subgroup analysis showed that MS was significantly associated with SUI in the subgroups of pre- and postmenopausal women (OR = 2.46, 95% CI 1.63, 3.73, p < 0.00001), and in the subgroups of other types of women (OR = 3.41, 95% CI 2.01, 5.77, p = 0.0003), and the differences were statistically significant.

Conclusions

Metabolic syndrome is associated with SUI in women and increases its risk.

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Funding

This study was funded by a Special research project of the National Clinical Research Base of Traditional Chinese Medicine in 2019 (grant number JDZX201920).

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Authors and Affiliations

  1. The People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, No. 602,817 Middle Road, Taijiang District, Fuzhou, 350004, Fujian, China

    Huirong Huang & Shaofang Miao

  2. Shandong Open University, Jinan, 250014, Shandong, China

    Xueqi Han

  3. The First People’s Hospital of Chongqing Liang Jiang New Area, Liang Jiang New Area, Chongqing, 401121, China

    Qinyu Liu

  4. School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, Fujian, China

    Jialu Xue & Zhenling Yu

Authors
  1. Huirong Huang
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  2. Xueqi Han
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  3. Qinyu Liu
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  4. Jialu Xue
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  5. Zhenling Yu
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  6. Shaofang Miao
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Contributions

H. Huang: project development, data collection, manuscript writing; X. Han and Q. Liu: data collection, manuscript writing; J. Xue and Z. Yu: assessed the risk of bias; S. Miao: checked the information extracted from the data and the results of the risk assessment.

Corresponding author

Correspondence to Huirong Huang.

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Study registration

This systematic review is register with PROSPERO (CRD42021231965).

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Huang, H., Han, X., Liu, Q. et al. Associations between metabolic syndrome and female stress urinary incontinence: a meta-analysis. Int Urogynecol J 33, 2073–2079 (2022). https://doi.org/10.1007/s00192-021-05025-0

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  • DOI: https://doi.org/10.1007/s00192-021-05025-0

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