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Glue mesh fixation in laparoscopic sacrocolpopexy: results at 3 years’ follow-up

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Abstract

Introduction and hypothesis

We assessed 3-year anatomic and functional results using synthetic glue to fix mesh in laparoscopic sacrocolpopexy.

Methods

Prospective multicenter cohort study in three academic urogynecology departments. Seventy consecutive patients with stage ≥ 3 POP-Q (Pelvic Organ Prolapse Quantification) anterior and/or apical prolapse underwent laparoscopic sacrocolpopexy using synthetic surgical glue to fix anterior and posterior meshes to the vagina. Patients were followed up at 1, 2 and 3 years. Primary outcome was anterior and apical anatomic success (POP-Q stage ≤ 1) at 3 years. Secondary outcomes comprised functional results (international quality of life and sexuality scales), mesh-related morbidity and urinary incontinence at 3 years.

Results

Mean age was 56.7 ± 1.2 years. Mean follow-up was 43 months. Anterior compartment anatomic success rate was 87% at 2 years (Ba, −2.4 cm; p < 0.0001) and 86.5% at 3 years (Ba, −2.3 cm; p < 0.0001); apical success was 96.3% at 2 years (C, −6.8 cm; p < 0.0001) and 97.3% at 3 years (C, −6.5 cm; p < 0.0001). All quality-of-life scores improved significantly and lastingly at 3 years: PFDI-20, PFIQ-7 and PISQ-12, respectively, p < 0.0001, p < 0.0001 and p = 0.01. There was one case of vaginal mesh exposure at 3 years (2.8%) and five of mesh shrinkage at 1 year (7.8%), none at 2 years and two at 3 years (5.4%). Urinary incontinence rate was 29.7% at 1 year, 14.8% at 2 years and 11.1% at 3 years.

Conclusion

Vaginal mesh adhesive in laparoscopic sacrocolpopexy remained effective at 3 years, with excellent tolerance and no specific complications. Anatomic and functional results were good and enduring in terms of both anterior and apical correction.

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References

  1. Wu JM, Kawasaki A, Hundley AF, Dieter AA, Myers ER, Sung VW. Predicting the number of women who will undergo incontinence and prolapse surgery, 2010 to 2050. Am J Obstet Gynecol. 2011;205(3):230.

    Article  Google Scholar 

  2. Olsen AL, Smith VJ, Bergstrom JO, Colling JC, Clark AL. Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol. 1997;89(4):501–6.

    Article  CAS  Google Scholar 

  3. Maher C, Feiner B, Baessler K, Schmid C. Surgical management of pelvic organ prolapse in women. Cochrane Database Syst Rev. 2013;4:CD004014.

    Google Scholar 

  4. Maher C, Feiner B, Baessler K, Christmann-Schmid C, Haya N, Brown J. Surgery for women with anterior compartment prolapse. Cochrane Database Syst Rev. 2016;11:CD004014.

    PubMed  Google Scholar 

  5. Akladios CY, Dautun D, Saussine C, Baldauf JJ, Mathelin C, Wattiez A. Laparoscopic sacrocolpopexy for female genital organ prolapse: establishment of a learning curve. Eur J Obstet Gynecol Reprod Biol. 2010;149(2):218–21.

    Article  Google Scholar 

  6. Nezhat CH, Nezhat F, Nezhat C. Laparoscopic sacral colpopexy for vaginal vault prolapse. Obstet Gynecol. 1994;84(5):885–8.

    CAS  PubMed  Google Scholar 

  7. Mustafa S, Amit A, Filmar S, Deutsch M, Netzer I, Itskovitz-Eldor J, et al. Implementation of laparoscopic sacrocolpopexy: establishment of a learning curve and short-term outcomes. Arch Gynecol Obstet. 2012;286(4):983–8.

    Article  Google Scholar 

  8. Bellón Juan M, Mar F-G, Marta R, et al. Bioassay of cyanoacrylate tissue adhesives used for intraperitoneal mesh fixation. J Biomed Mater Res B Appl Biomater. 2015. https://doi.org/10.1002/jbm.b.33558.

  9. Reynvoet E, Van Cleven S, Van Overbeke I, et al. The use of cyanoacrylate sealant as simple mesh fixation in laparoscopic ventral hernia repair: a large animal evaluation. Hernia J Hernias Abdom Wall Surg. 2015;19(4):661–70.

    Article  CAS  Google Scholar 

  10. Estrade JP, Gurriet B, Franquebalme JP, Chinchole JM, Glowaczower E, Ferry C, et al. Laparoscopic sacrocolpopexy with a vaginal prosthetic adhesive. Gynecol Obstet Fertil. 2015;43(6):419–23.

    Article  Google Scholar 

  11. Panel P, Soffray F, Roussillon E, Devins C, Brouziyne M, Abramowicz S. Glue mesh fixation: feasibility, tolerance and complication assessment. Results 24 months after laparoscopic sacrocolpopexy. J Gynecol Obstet. Hum Reprod. 2017;46(4):333–8.

    CAS  Google Scholar 

  12. Willecocq C, Pizzoferrato A-C, Fauconnier A, Bader G. Use of glue in laparoscopic sacrocolpopexy. A comparative study about 32 cases. Gynécologie Obstétrique Fertil. 2014;42(12):822–6.

    Article  CAS  Google Scholar 

  13. Lamblin G, Dubernard G, de Saint Hilaire P, Jacquot F, Chabert P, Chene G, et al. Assessment of synthetic glue for mesh attachment in laparoscopic sacrocolpopexy: a prospective multicenter pilot study. J Minim Invasive Gynecol. 2017;24(1):41–7.

    Article  Google Scholar 

  14. Haylen BT, Freeman RM, Lee J, Swift SE, Cosson M, Deprest J, et al. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint terminology and classification of the complications related to native tissue female pelvic floor surgery. Int Urogynecology J. 2012;23(5):515–26.

    Article  Google Scholar 

  15. Costantini E, Mearini L, Lazzeri M, Bini V, Nunzi E, di Biase M, et al. Laparoscopic versus abdominal sacrocolpopexy: a randomized, controlled trial. J Urol. 2016;196(1):159–65.

    Article  Google Scholar 

  16. Sarlos D, Kots L, Ryu G, Schaer G. Long-term follow-up of laparoscopic sacrocolpopexy. Int Urogynecol J. 2014;25(9):1207–12.

    Article  Google Scholar 

  17. Ganatra AM, Rozet F, Sanchez-Salas R, Barret E, Galiano M, Cathelineau X, et al. The current status of laparoscopic sacrocolpopexy: a review. Eur Urol. 2009;55(5):1089–103.

    Article  Google Scholar 

  18. Cosson M, Vinatier D, Rajabally R, Querleu D, Crepin G. Rejection of stapled prosthetic mesh after laparoscopic sacropexy. Int Urogynecol J Pelvic Floor Dysfunct. 1999;10(5):349–50.

    Article  CAS  Google Scholar 

  19. de Goede B, Klitsie PJ, van Kempen BJH, Timmermans L, Jeekel J, Kazemier G, et al. Meta-analysis of glue versus sutured mesh fixation for Lichtenstein inguinal hernia repair. Br J Surg. 2013;100(6):735–42.

    Article  Google Scholar 

  20. Sergent F, Resch B, Loisel C, Bisson V, Schaal J-P, Marpeau L. Mid-term outcome of laparoscopic sacrocolpopexy with anterior and posterior polyester mesh for treatment of genito-urinary prolapse. Eur J Obstet Gynecol Reprod Biol. 2011;156(2):217–22.

    Article  Google Scholar 

  21. Nygaard I, Brubaker L, Zyczynski HM, Cundiff G, Richter H, Gantz M, et al. Long-term outcomes following abdominal sacrocolpopexy for pelvic organ prolapse. JAMA. 2013;309(19):2016–24.

    Article  CAS  Google Scholar 

  22. Shepherd JP, Higdon HL 3rd, Stanford EJ, Mattox TF. Effect of suture selection on the rate of suture or mesh erosion and surgery failure in abdominal sacrocolpopexy. Female Pelvic Med Reconstr Surg. 2010;16(4):229–33.

    Article  Google Scholar 

  23. Tan-Kim J, Menefee SA, Lippmann Q, Lukacz ES, Luber KM, Nager CW. A pilot study comparing anatomic failure after sacrocolpopexy with absorbable or permanent sutures for vaginal mesh attachment. Perm J. Fall. 2014;18(4):40–4.

    Google Scholar 

  24. Pacquée S, Nawapun K, Claerhout F, Werbrouck E, Veldman J, D’hoore A, et al. Long-term assessment of a prospective cohort of patients undergoing laparoscopic Sacrocolpopexy. Obstet Gynecol. 2019;134(2):323–32.

    Article  Google Scholar 

  25. Thibault F, Costa P, Thanigasalam R, Seni G, Brouzyine M, Cayzergues L, et al. Impact of laparoscopic sacrocolpopexy on symptoms, health-related quality of life and sexuality: a medium-term analysis. BJU Int. 2013;112(8):1143–9.

    Article  Google Scholar 

  26. Wagner L, Boileau L, Delmas V, Haab F, Costa P. Surgical treatment of prolapse using coelioscopic promontofixation: techniques and results. Prog En Urol J Assoc Fr Urol Société Fr Urol. 2009;19(13):994–1005.

    CAS  Google Scholar 

  27. LeClaire EL, Mukati MS, Juarez D, White D, Quiroz LH. Is de novo stress incontinence after sacrocolpopexy related to anatomical changes and surgical approach? Int Urogynecol J. 2014;25(9):1201–6.

    Article  Google Scholar 

  28. Leruth J, Fillet M, Waltregny D. Incidence and risk factors of postoperative stress urinary incontinence following laparoscopic sacrocolpopexy in patients with negative preoperative prolapse reduction stress testing. Int Urogynecol J. 2013;24(3):485–91.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Urogynecology, Université Claude Bernard Lyon 1, Hôpital Femme Mère Enfant, 59 Boulevard Pinel, 69677, Lyon-Bron, France

    G. Lamblin, G. Chene & S. Moret

  2. Hôpital de la Croix Rousse, Service de Chirurgie Gynécologique, 103 Grande Rue de la Croix Rousse, 69317, Lyon cedex 04, France

    S. Warembourg

  3. Centre Hospitalier Lyon Sud, Service de Chirurgie Gynécologique, Chemin du Grand Revoyet, 69495, Pierre Bénite, France

    F. Jacquot & F. Golfier

Authors
  1. G. Lamblin
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  2. G. Chene
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  3. S. Warembourg
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  4. F. Jacquot
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  5. S. Moret
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  6. F. Golfier
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Contributions

Gery Lamblin: Protocol/Project development, Manuscript writing, Editing.

Gautier Chene: Data collection, Investigator.

Sophie Warembourg: Project development, Data collection, Investigator.

Franck Jacquot: Data collection, Investigator.

Stéphanie Moret: Clinical research associate, Data collection.

François Golfier: Project development, Data collection, Investigator, Supervisor.

All authors read and approved the final version.

Corresponding author

Correspondence to G. Lamblin.

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Clinical trials registration number: NCT02011373

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Lamblin, G., Chene, G., Warembourg, S. et al. Glue mesh fixation in laparoscopic sacrocolpopexy: results at 3 years’ follow-up. Int Urogynecol J 33, 2533–2541 (2022). https://doi.org/10.1007/s00192-021-04764-4

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  • DOI: https://doi.org/10.1007/s00192-021-04764-4

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