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Comparison of the effects of trospium and solifenacin on intraocular pressure and tear secretion in patients with overactive bladder

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Abstract

Introduction and hypothesis

Comparison of the effects of trospium and solifenacin used for the treatment of overactive bladder (OAB) on intraocular pressure (IOP) and tear secretion.

Methods

This study was planned as a prospective study and was conducted at a single center between October 2014 and April 2016. OAB patients were included in the study following an ophthalmic examination, IOP measurement with an applanation tonometer, and tear secretion measurement with the Schirmer I test in the ophthalmology outpatient department. The patients were started with trospium 30 mg oral bid or solifenacin 5 mg oral qd. They were then followed up at the 4th and 12th weeks.

Results

A total of 225 OAB patients with a mean age of 47.80 (18–75) years were evaluated. The mean age was 47.41 ± 12.65 years in the trospium group (n = 104) and 48.14 ± 11.82 years in the solifenacin group (n = 121) with no statistically significant difference. When the two medications were compared, no statistically significant difference was observed at the 4th and 12th weeks in terms of IOP (p = 0.988, p = 0.822) and dry eye (p = 0.764, p = 0.581).

Conclusions

No statistically significant difference was observed between trospium and solifenacin in terms of their effects on IOP and tear secretion in OAB patients. We therefore concluded that the effects of trospium and solifenacin on IOP and tear secretion changes were similar in OAB patients without comorbidities.

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Funding

Permission was obtained for this study and complied with the Helsinki Declaration.

Author information

Authors and Affiliations

  1. University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital, Urology, Bursa, Turkey

    Ali Riza Turkoglu, Muhammet Guzelsoy & Soner Coban

  2. University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital, Ophtalmatology, Bursa, Turkey

    Neslihan Parmak Yener

  3. University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital, Family Medicine, Bursa, Turkey

    Hakan Demirci

Authors
  1. Ali Riza Turkoglu
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  2. Neslihan Parmak Yener
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  3. Muhammet Guzelsoy
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  4. Soner Coban
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  5. Hakan Demirci
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Contributions

Ali Riza Turkoglu: Project development, Data collection, Manuscript writing.

Neslihan Parmak Yener: Project development, Data collection, Manuscript writing.

Muhammet Guzelsoy: Data collection, Manuscript writing.

Soner Coban: Data collection, Manuscript writing.

Hakan Demirci: Data collection, Manuscript writing.

Corresponding author

Correspondence to Ali Riza Turkoglu.

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The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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Turkoglu, A.R., Parmak Yener, N., Guzelsoy, M. et al. Comparison of the effects of trospium and solifenacin on intraocular pressure and tear secretion in patients with overactive bladder. Int Urogynecol J 32, 173–178 (2021). https://doi.org/10.1007/s00192-020-04473-4

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  • DOI: https://doi.org/10.1007/s00192-020-04473-4

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