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Preoperative predictors and a prediction score for perception of improvement after mesh prolapse surgery

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Abstract

Introduction and hypothesis

Pelvic organ prolapse (POP) surgery using a mesh has a complication rate of 26%, and an estimated 10% of those operated on do not consider it brings improvement. The objective of this study was to identify preoperative predictors of improvement after POP repair with mesh to develop a predictive score.

Methods

This is a secondary analysis of the randomized multicenter trial PROSPERE, which compared morbidity after prolapse repair with mesh according to the vaginal or laparoscopic approach. Improved women [PGI-I score at 1-year follow-up = 1 (much better) or 2 (better)] were compared with unimproved women. Two hundred fifty-five women were included to derive the prediction score based on multiple logistic regression. An internal validation by bootstrapping estimated the unbiased performance of the model.

Results

Criteria independently related to improvement were: (1) cystocele stage > II [OR: 2.93 95% CI (1.22–7.04), p = 0.015]; (2) preoperative expectation related to bulge symptom improvement [OR: 2.57 95% CI (1.07–6.04), p = 0.031] and (3) absence of chronic pelvic pain [OR: 4.55 95% CI (1.77–11.46), p = 0.001]. A score (scored from 0 to 11) was constructed from the aOR of the predictive model: the ROC-AUC of the score was 0.75, and a score ≥ 9 predicted a 97% chance of improvement (95% CI 92–99), with a specificity of 85% (95% CI 68–94). The ROC-AUC corrected for optimism by the bootstrap procedure was 0.70.

Conclusions

This score could be used by surgeons in preoperative counseling of women.

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Authors and Affiliations

  1. EA 7285 Research Unit “Risk and Safety in Clinical Medicine for Women and Perinatal Health”, Versailles-Saint-Quentin University (UVSQ), 78180, Montigny-le-Bretonneux, France

    Chloé Chattot, Xavier Deffieux & Arnaud Fauconnier

  2. Department of Gynecology and Obstetrics, Intercommunal Hospital Centre of Poissy-Saint-Germain-en-Laye, 10 rue du Champ Gaillard, BP 3082, 78300, Poissy Cedex, France

    Chloé Chattot & Arnaud Fauconnier

  3. Department of Gynecology and Obstetrics and Reproductive Medicine, APHP, Hôpital Antoine Béclère, 92140, Clamart, France

    Xavier Deffieux

  4. Gynecological Surgery Unit, Centre Hospitalier Universitaire Jeanne de Flandre, 59 000, Lille, France

    Jean-Philippe Lucot

  5. Department of Obstetrics and Gynecology and Reproductive Medicine, Centre Hospitalier Universitaire de Poitiers, 86021, Poitier, France

    Xavier Fritel

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  1. Chloé Chattot
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  2. Xavier Deffieux
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  5. Arnaud Fauconnier
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Correspondence to Chloé Chattot.

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This research was supported by a grant from Institut de Recherche en Santé de la Femme (Women’s Health Research Institute).

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Chattot, C., Deffieux, X., Lucot, JP. et al. Preoperative predictors and a prediction score for perception of improvement after mesh prolapse surgery. Int Urogynecol J 31, 1393–1400 (2020). https://doi.org/10.1007/s00192-019-03953-6

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  • DOI: https://doi.org/10.1007/s00192-019-03953-6

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