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Vitamin E as alternative local treatment in genitourinary syndrome of menopause: a randomized controlled trial

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Introduction and hypothesis

Genitourinary syndrome of menopause is a major health concern in postmenopausal women. This study was aimed at comparing the effect of a vitamin E vaginal suppository with that of conjugated estrogen vaginal cream on sexual function in postmenopausal women with genitourinary syndrome of menopause.


This survey was carried out on 52 postmenopausal women aged 40–65 years who had been referred to gynecology clinics in Mashhad city, during 2013–2014. Keeping β = 0.1, the power was calculated to be 90%. The patients were randomly divided into two groups: vitamin E vaginal suppository and conjugated estrogen vaginal cream. Participants used the medications for 12 weeks. They were visited at the 4th, 8th, and 12th weeks. Validated Abbreviated Sexual Function Questionnaire (ASFQ), as the primary outcome measure, and a demographic information questionnaire, were used to collect data at each visit. Data were analyzed using SPSS and p < 0.05 was considered statistically significant.


Mean overall scores of the ASFQ were increased significantly in both groups during the course of the study, compared with baseline (p < 0.001). However, the mean ASFQ scores of the two treatments did not differ significantly.


Improved scores of ASFQ after the 12th week showed that the treatment was successful in both groups. Therefore, a vitamin E vaginal suppository may be an alternative to vaginal estrogen in relieving the symptoms of vaginal atrophy in postmenopausal women, especially those not able to use hormone therapy or have low compliance.

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The authors wish to thank the vice chancellor for research and technology of the Mashhad University of Medical Sciences for his financial support of the study, Dr Majid Khadem-Rezaiyan for help in statistical analysis, and Mr Mohammad Alizadeh Noughani for providing language help.


This study is based on a project that was funded by Mashhad University of Medical Sciences (grant number 911186).

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Correspondence to Malihe Hassanzadeh.

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Golmakani, N., Parnan Emamverdikhan, A., Zarifian, A. et al. Vitamin E as alternative local treatment in genitourinary syndrome of menopause: a randomized controlled trial. Int Urogynecol J 30, 831–837 (2019).

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