International Urogynecology Journal

, Volume 29, Issue 7, pp 961–966 | Cite as

Comparison of inflammatory urine markers in patients with interstitial cystitis and overactive bladder

  • Akira Furuta
  • Tokunori Yamamoto
  • Yasuyuki Suzuki
  • Momokazu Gotoh
  • Shin Egawa
  • Naoki Yoshimura
Original Article


Introduction and hypothesis

Chronic inflammatory conditions seem to be a shared characteristic in patients with interstitial cystitis (IC) and overactive bladder (OAB). Thus, we measured 40 inflammatory urine markers in IC patients with or without Hunner’s lesions (HIC and NHIC respectively) and OAB patients.


Urine was collected from consecutive HIC patients, NHIC patients, and age and gender-matched OAB patients with no history of IC, recurrent urinary tract infection or bladder cancer. The diagnosis of IC was based on the Asian IC guideline criteria. A representative 40 inflammatory growth factors, cytokines, and chemokines in urine were measured using a MILLIPLEX immunoassay kit. Statistical differences in these markers among the groups were determined by nonparametric ANOVA followed by multiple comparison test. The diagnostic efficiency of these markers was measured using receiver operating characteristic analysis.


Vascular endothelial growth factor (VEGF), interleukin-1α (IL-1α), IL-6, and chemokines including CCL2, CCL5, CXCL1, CXCL8, and CXCL10 were significantly increased in HIC (n = 30) and NHIC (n = 30) patients compared with OAB (n = 28) patients. The significant increases in CXCL8 and CXCL10 were also found in HIC patients compared with NHIC patients. However, there were no significant differences in the other urine markers among the groups. Area under the curves for VEGF, CXCL10, CXCL8, IL-1α, CCL5, CCL2, IL-6, and CXCL1 to detect IC in these patients were 0.87, 0.86, 0.81, 0.80, 0.80, 0.71, 0.66, and 0.50 respectively.


The increases in angiogenesis-associated proteins such as VEGF and CXCL10 may be pathophysiologically important for the development of IC.


Angiogenesis CXCL10 Interstitial cystitis Overactive bladder Vascular endothelial growth factor 



Hunner’s type interstitial cystitis


Interstitial cystitis




Non-Hunner’s type interstitial cystitis


Overactive bladder


O’Leary–Sant score symptom indexes


O’Leary–Sant score problem indexes


Visual analog scale


Vascular endothelial growth factor



This study was supported by JSPS KAKENHI grant number JP15K10633.

Compliance with ethical standards

Conflicts of interest



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Copyright information

© The International Urogynecological Association 2018

Authors and Affiliations

  1. 1.Department of UrologyJikei University School of MedicineTokyoJapan
  2. 2.Department of UrologyNagoya University Graduate School of MedicineNagoyaJapan
  3. 3.Department of UrologyTokyo Metropolitan Rehabilitation HospitalTokyoJapan
  4. 4.Department of UrologyUniversity of Pittsburgh School of MedicinePittsburghUSA

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