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Intravesical treatment of painful bladder syndrome: a systematic review and meta-analysis

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Abstract

Introduction and hypothesis

The objective of the study was to assess the effectiveness of intravesical treatment for painful bladder syndrome (PBS).

Methods

A systematic review was performed until December 31, 2010. The selection criteria included only randomized controlled trials of PBS patients who received intravesical treatment. The primary outcomes measures were clinical and urodynamic parameters. Relative risk and mean differences were used for binary and continuous outcomes respectively, with confidence interval of 95%.

Results

The search strategy identified 770; however, only 28 eligible trials met methodological requirements for complete analysis. Altogether, the review included four treatment modalities: resiniferatoxin, Bacillus Calmette–Guérin (BCG), oxybutynin, and alkalinized lidocaine. Meta-analysis of BCG therapy showed improvement in symptoms according to the Wisconsin Interstitial Cystitis Symptom Inventory, but no difference in 24-h urinary frequency.

Conclusions

Meta-analysis showed an improvement exclusively of the symptoms as measured by the Wisconsin Interstitial Cystitis Inventory, but not in 24-h urinary frequency, with BCG therapy. Further randomized clinical trials, including trials of more recent drugs, are required for evaluation of intravesical therapies for PBS.

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Acknowledgments

The authors would like to thank Wanderley Marques Bernardo for his contribution to the statistic analysis portion of the study.

Conflicts of interest

None.

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Authors and Affiliations

  1. Urogynecology Division, Department of Gynecology and Obstetrics, USP, Sao Paulo, Brazil

    P. K. Matsuoka, J. M. Haddad, A. M. Pacetta & E. C. Baracat

  2. Av. Onze de Junho, 911—apto 612—Vila Clementino, São Paulo, São Paulo, 04041-053, Brazil

    P. K. Matsuoka

Authors
  1. P. K. Matsuoka
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  2. J. M. Haddad
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  3. A. M. Pacetta
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  4. E. C. Baracat
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Corresponding author

Correspondence to P. K. Matsuoka.

Additional information

This article is discussed in the editorial available at doi:10.1007/s00192-012-1751-x.

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Matsuoka, P.K., Haddad, J.M., Pacetta, A.M. et al. Intravesical treatment of painful bladder syndrome: a systematic review and meta-analysis. Int Urogynecol J 23, 1147–1153 (2012). https://doi.org/10.1007/s00192-012-1686-2

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  • DOI: https://doi.org/10.1007/s00192-012-1686-2

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