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Prospective randomized comparison of oxybutynin, functional electrostimulation, and pelvic floor training for treatment of detrusor overactivity in women

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Abstract

The purpose of this study is to compare the effectiveness of oxybutynin, functional electrostimulation (FES), and pelvic floor training (PFT) for treatment of women with detrusor overactivity. Sixty-four subjects were randomized to oxybutynin (n = 22), FES (n = 21), or PFT (n = 21). Women were evaluated before and after completion of 12 weeks of treatment by subjective response, voiding diary, and urodynamic test. There was subjective symptomatic improvement in 77% of the women treated with oxybutynin, 52% with FES, and 76% with PFT. Urgency resolved in 64% of women treated with oxybutynin, 52% with FES, and in 57% with PFT. Urodynamic evaluation was normal in 36% treated with oxybutynin, 57% with FES, and 52% with PFT. Maximum detrusor involuntary contraction pressure decreased in all groups (p < 0.05). All treatments were equally effective. Subjective reduction of urge-incontinence episodes was associated with symptomatic improvement.

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Authors and Affiliations

  1. Department of Urogynecology, Federal University of São Paulo, R. Loefgreen, 1654/14, Vila. Clementino, 04040-002, São Paulo, Brazil

    Raquel M. Arruda, Rodrigo A. Castro, Gabriela C. Sousa, Marair G. F. Sartori, Edmund C. Baracat & Manoel J. B. C. Girão

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  1. Raquel M. Arruda
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  2. Rodrigo A. Castro
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  3. Gabriela C. Sousa
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  4. Marair G. F. Sartori
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  5. Edmund C. Baracat
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  6. Manoel J. B. C. Girão
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Correspondence to Raquel M. Arruda.

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Arruda, R.M., Castro, R.A., Sousa, G.C. et al. Prospective randomized comparison of oxybutynin, functional electrostimulation, and pelvic floor training for treatment of detrusor overactivity in women. Int Urogynecol J 19, 1055–1061 (2008). https://doi.org/10.1007/s00192-008-0586-y

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  • DOI: https://doi.org/10.1007/s00192-008-0586-y

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