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The usefulness of antibiotic prophylaxis in invasive urodynamics in postmenopausal female subjects

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Abstract

This study aims to define the usefulness of antibiotic prophylaxis of urinary tract infection (UTI) in postmenopausal female undergoing invasive urodynamics (IU). Two hundred sixty-two postmenopausal females underwent IU. Before urodynamics, all females were double blindly randomized in two age stratified groups. Group 1 (130 patients) received oral antibiotic prophylaxis with a single 400-mg dose of norfloxacin. Group 2 (132 patients) received norfloxacin placebo. Statistical analysis was performed by a χ 2 test to evaluate differences between groups for UTI incidence rate. Fifty-four patients of 262 (20.6%) resulted affected by UTI [24 of 130 subjects who received antibiotic prophylaxis (18.4%) and 30 of 132 subjects who received placebo (22.7%)]. There was no statically significant difference (P = 0.242) regarding UTI incidence rate between patients who received and those who did not received antibiotic prophylaxis. UTI incidence rate in postmenopausal women undergoing urodynamics is not affected by administration of antibiotic prophylaxis at the desired level of efficacy.

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Authors and Affiliations

  1. Department of Urology, University of Trieste, Trieste, Italy

    Salvatore Siracusano & Roberto Knez

  2. Department of Urology, Portogruaro Hospital, Portogruaro, Italy

    Anna Tiberio

  3. Department of Urology, San Bonifacio Hospital, San Bonifacio, Italy

    Vito Alfano

  4. Department of Urology, University of Perugia, Perugia, Italy

    Antonella Giannantoni

  5. Department of Oncology, PF Calvi Hospital, Noale, Italy

    Giovanni Pappagallo

Authors
  1. Salvatore Siracusano
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  2. Roberto Knez
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  3. Anna Tiberio
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  4. Vito Alfano
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  5. Antonella Giannantoni
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  6. Giovanni Pappagallo
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Correspondence to Salvatore Siracusano.

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Siracusano, S., Knez, R., Tiberio, A. et al. The usefulness of antibiotic prophylaxis in invasive urodynamics in postmenopausal female subjects. Int Urogynecol J 19, 939–942 (2008). https://doi.org/10.1007/s00192-008-0570-6

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  • DOI: https://doi.org/10.1007/s00192-008-0570-6

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