Bias in research and conflict of interest: why should we care?
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Medical journals are a prime source of professional information for doctors and have a major impact on patient care. Editors and authors are, even more so than the practising clinician, trustees of the public good. Our role is to provide information that is as ‘true’ as we can make it. To this purpose, it is imperative that bias in published research be reduced as far as possible. In fact, “the entire infrastructure of science [...] is built on the fundamental notion of eliminating, or at least controlling for, [...] bias” . In therapeutic medicine, the double-blind multicentre randomised controlled trial (RCT) is seen as the ‘gold standard’ of bias reduction—developed in response to higher scientific and regulatory standards and to fulfil the precepts of evidence-based medicine.
Unfortunately, it is precisely the therapeutic multicentre RCTs that are subject to the most powerful form of bias in modern medicine because the great majority of such trials are now (as opposed to...
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- 3.Mathews W (2005) A ghost story: at medical journals, writers paid by industry play big role. Wall Street J A1 (Dec 13)Google Scholar
- 5.Bhandari M, Busse JW, Jackowski D et al (2004) Association between industry funding and statistically significant pro-industry findings in medical and surgical randomized trials (see comment). CMAJ Can Med Assoc J 170(4):477–480Google Scholar
- 9.Goetzsche P (2005) Research integrity and pharmaceutical industry sponsorship. Med J Aust 182(11):549Google Scholar
- 12.Andersen NV (2006) Gunnar lose vs. Yamanouchi. Ugeskrift for Laeger 168(6):546Google Scholar
- 16.Moynihan R, Cassels A (2005) Selling sickness: how drug companies are turning us all into patients. G. Allen, Sydney, AustraliaGoogle Scholar
- 17.N.N. World Association of Medical Editors Recommendations on Publication Ethics Policies for Medical Journals, 2006 at: http://www.wame.org/, accessed 15.5.06Google Scholar
- 18.N.N. Uniform Requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication: International Committee of Medical Journal Editors, 2006, at: http://www.icmje.org/, accessed 15.5.06Google Scholar
- 19.Korn, D. and S. Ehringhaus, Principles for strengthening the integrity of clinical research. 2006, Public Library of Science at: http://www.plosclinicaltrials.orgGoogle Scholar
- 20.N.N. World Medical Association Declaration of Helsinki, 2004, at: http://www.wma.net/e/policy/b3.htm., accessed 15.5.06Google Scholar
- 21.4th Annual Patient Recruitment for Clinical Trials. 2006: New York, at: www.marcusevansbb.com/recruitment, accessed 10.6.06Google Scholar
- 24.Angell M (2004) The truth about the drug companies: how they deceive us and what to do about it. Random House, New YorkGoogle Scholar
- 1.Kassirer JP (2005) On the take. Oxford University Press, New YorkGoogle Scholar
- 2.Krimsky S (2003) Science in the private interest. Rowman & Littlefield, Lanham, MDGoogle Scholar
- 3.Angell M (2004) The truth about the drug companies: how they deceive us and what to do about it. Random House, New YorkGoogle Scholar
- 4.Moynihan R, Cassels A (2005) Selling sickness: how drug companies turning us all into patients. G. Allen, SydneyGoogle Scholar