Abstract
This study investigated the selective laser sintering (SLS) of aliphatic-polycarbonate/hydroxyapatite (a-PC/HA) composite scaffolds for medical applications. The effects of material ratios and SLS processing parameters on the porosity, microstructures and mechanical properties of the samples were observed. The optimized proportion in the a-PC/HA composite was found to be 10 wt% HA. The processing parameters were optimized as: 10 W of laser power, 2000 mm/s of scan speed, 0.15 mm of scan spacing, and 0.17 mm of layer thickness. With the optimized process, the scaffold porosity and compressive module were increased to 77.36 % and 26 MPa, respectively. The pores were interconnected, indicating the existence of more space for cell ingrowth and the improvement in the load capability of bone scaffold. The nanoscale HA particles were fully or partially embedded in a-PC matrix and did not decompose during the SLS processing. Crystalline behavior, bioactive activity, and osteoconduction, beneficial for bone ingrowth, scarcely changed before and after sintering. The successful manufacturing of complex scaffold with smooth surface demonstrated that surface roughness could be controlled by optimizing HA content and adjusting the processing parameters. The a-PC/HA composite powder could be used to manufacture complex porous parts by using the SLS process for medical applications.
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Langer R, Tirrell DA (2004) Designing materials for biology and medicine. Nature 428(6982):487–492
Yu H, Matthew HW, Wooley PH, Yang SY (2008) Effect of porosity and pore size on microstructures and mechanical properties of poly-epsilon-caprolactone-hydroxyapatite composites. J Biomed Mater Res B Appl Biomater 86(2):541–547
Armillotta A, Pelzer R (2008) Modeling of porous structures for rapid prototyping of tissue engineering scaffolds. Int J Adv Manuf Technol 39:501–511
Salmoria GV, Fancello EA, Roesler CRM, Dabbas F (2012) Functional graded scaffold of HDPE/HA prepared by selective laser sintering: microstructure and mechanical properties. Int J Adv Manuf Technol 65(9–12):1529–1534
Shuai C, Yang B, Peng S, Li Z (2013) Development of composite porous scaffolds based on poly(lactide-co-glycolide)/nano-hydroxyapatite via selective laser sintering. Int J Adv Manuf Technol 69(1–4):51–57
Chua CK, Leong KF, Tan KH, Wiria FE, Cheah CM (2003) Development of a tissue engineering scaffold structure library for rapid prototyping. Int J Adv Manuf Technol 21(4):302–312
Santos DM, Leong KF, Chua CK (2001) Rapid prototyping applications in medicine. Int J Adv Manuf Technol 18(2):103–117
Yan CZ, Shi YS, Wei QS, Zhang S (2009) Investigation into the pressing parameter of selected laser sintering carbon fiber/nylon composite powder. China thirteenth special processing Symposium of China, pp 496–498
Salmoria GV, Ahrens CH, Klauss P, Paggi RA, Oliveira RG, Lago A (2007) Rapid manufacturing of PE with controlled pore gradients using SLS. Mater Res 10:214–221
Schmidt M, Pohle D, Rechtenwald T (2007) Selective laser sintering of PEEK. Int J Adv Manuf Technol 56(1):205–208
Wu L, Ding J (2005) Effects of porosity and pore size on in vitro degradation of three-dimensional porous poly(D, L-lactide-co-glycolide) scaffolds for tissue engineering. J Biomed Mater Res A 75(4):767–777
Shuai C, Mao Z, Lu H, Nie Y, Hu H, Peng S (2013) Fabrication of porous polyvinyl alcohol scaffold for bone tissue engineering via selective laser sintering. Biofabrication 5(1):873–886
Shuai C, Feng P, Cao C, Peng S (2013) Processing and characterization of laser sintered hydroxyapatite scaffold for tissue engineering. Biotechnol Bioproc Eng 18(3):520–527
Wiria FE, Chua CK, Leong KF, Quah ZY, Chandrasekaran M, Lee MW (2008) Improved biocomposite development of poly(vinyl alcohol) and hydroxyapatite for tissue engineering scaffold fabrication using selective laser sintering. J Mater Sci Mater Med 19(3):989–996
Zhang Y, Hao L, Savalani MM, Harris RA, Tanner KE (2008) Characterization and dynamic mechanical analysis of selective laser sintered hydroxyapatite-filled polymeric composites. J Biomed Mater Res A 86(3):607–616
Wang H, Li Y, Zuo Y, Li J, Ma S, Cheng L (2007) Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering. Biomaterials 28(22):3338–3348
Laurea S (2009) Polycaprolactone/hydroxyapitite scaffolds for bone tissue engineering. Drexel University, Philadelphia
Eosoly S, Vrana NE, Lohfeld S, Hindie M, Looney L (2012) Interaction of cell culture with composition effects on the mechanical properties of polycaprolactone-hydroxyapatite scaffolds fabricated via selective laser sintering (SLS). Mat Sci Eng C-Mater 32(8):2250–2257
Mazzoli A (2013) Selective laser sintering in biomedical engineering. Med Biol Eng Comput 51:245–256
Ho HCH, Gibson I, Cheung WL (1999) Effects of energy density on morphology and properties of selective laser sintered polycarbonate. J Mater Process Technol 90:204–210
Ho HCH, Cheung WL, Gibson I (2003) Morphology and properties of selective laser sintered bisphenol a polycarbonate. Ind Emg Chem Res 42(9):1850–1862
Fan KM, Cheung WL, Gibson I (2005) Movement of powder bed material during the selective laser sintering of bisphenol-A polycarbonate. Rapid Prototyp J 11(4):188–198
Liao J, Zhang L, Zuo Y, Wang H, Li J, Zou Q, Li Y (2009) Development of nanohydroxyapatite/polycarbonate composite for bone repair. J Biomater Appl 24(1):31–45
Zheng YL, Li YL, Liu X, Liu ZY, Yang W, Li W, Yang MB (2008) Mechanical and thermal properties of polycarbonate/hydroxyapatite nanocomposites. J Polym Mater Sci Eng 24(4):62–65
Dong QX, Chen QJ, Yang W, Zheng YL, Liu X, Li YL, Yang MB (2008) Thermal properties and flame retardancy of polycarbonate/hydroxyapatite nanocomposite. J Appl Polym Sci 109(1):659–663
Feng J, Zhuo RX, Zhang XZ (2012) Construction of functional aliphatic polycarbonates for biomedical applications. Prog Polym Sci 37:211–236
Song X, Shi Y, Song P, Wei Q, Li W (2014) Effects of the processing parameters on porosity of selective laser sintered aliphatic polycarbonate. In: International Conference on Mechatronics, Robotics and Automation, Zhuhai, China. Trans Tech Publications Ltd, pp 1000–1004
Savalani MM, Hao L, Dickens PM, Zhang Y, Tanner KE, Harris RA (2012) The effects and interactions of fabrication parameters on the properties of selective laser sintered hydroxyapatite polyamide composite biomaterials. Rapid Prototyp J 18(1):16–27
Tan KH, Chua CK, Leong KF, Cheah CM, Cheang P, Abu Bakar MS, Cha SW (2003) Scaffold development using selective laser sintering of polyetheretherketone–hydroxyapatite biocomposite blends. Biomaterials 24:3115–3123
Harris RA, Tanner KE, Zhang Y, Hao L, Savalani MM (2007) Fabrication of porous bioactive structures using the selective laser sintering technique. J Eng Med 221(8):873–886
Lima DD, Lemperle SM, Chen PC, Holmes RE, Colwell CW (1998) Bone response to implant surface morphology. J Arthroplasty 13(8):928–934
Yuan HP, Kurashina K, de Bruijn JD, Li YB, de Groot K, Zhang XD (1999) A preliminary study on osteoinduction of two kinds of calcium phosphate ceramics. Biomaterials 20(19):1799–1806
Karageorgiou V, Kaplan D (2005) Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 26(27):5474–5491
Kruth JP, Levy G, Klocke F, Childs THC (2007) Consolidation phenomenon in laser and power bed-based layered manufacturing. CIRP Ann 56(2):730–759
Kuboki Y, Takita H, Kobayashi D, Tsuruga E, Inoue M, Murata M, Nagai N, Dohi Y, Ohgushi H (1998) BMP-induced osteogenesis on the surface of hydroxyapatite with geometrically feasible and nonfeasible structures: topology of osteogenesis. J Biomed Mater Res 39(2):190–199
Hildebrand T, Laib A, Muller R, Dequeker J, Ruegsegger P (1999) Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J Bone Miner Res Off J Am Soc Bone Miner Res 14(7):1167–1174
Itala AI, Ylanen HO, Ekholm C, Karlsson KH, Aro HT (2001) Pore diameter of more than 100 mm is not requisite for bone ingrowth in rabbits. J Biomed Mater Res 58(6):679–683
Hulbert SF, Young FA, Mathews RS, Klawitter JJ, Talbert CD, Stelling FH (1970) Potential of ceramic materials as permanently implantable skeletal prostheses. J Biomed Mater Res 4(3):433–456
Lin ASP, Barrows TH, Cartmell SH, Guldberg RE (2003) Microarchitectural and mechanical characterization of oriented porous polymer scaffolds. Biomaterials 24(3):481–489
Liu K, Shi Y, He W, Li C, Wei Q, Liu J (2012) Densification of alumina components via indirect selective laser sintering combined with isostatic pressing. Int J Adv Manuf Technol 67(9–12):2511–2519
Hon KKB, Gill TJ (2004) Experimental investigation into the selective laser sintering of silicon carbide polyamide composites. J Eng Manuf 218(10):1249–1256
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XiaoHui, S., Wei, L., PingHui, S. et al. Selective laser sintering of aliphatic-polycarbonate/hydroxyapatite composite scaffolds for medical applications. Int J Adv Manuf Technol 81, 15–25 (2015). https://doi.org/10.1007/s00170-015-7135-x
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DOI: https://doi.org/10.1007/s00170-015-7135-x