Skip to main content
Log in

Incorporation of axiomatic design theory into design of a microchannel system for uniform and size-controllable microspheres

  • ORIGINAL ARTICLE
  • Published:
The International Journal of Advanced Manufacturing Technology Aims and scope Submit manuscript

Abstract

This paper proposes a design methodology for the conceptual design of microchannel systems by applying axiomatic design theory (ADT). The microchannel system concerned in this paper is for the purpose of preparing uniform microspheres based on the phase separation principle and technique. There are two general design goals for this system: controllability of the size of microspheres and uniformity, or narrow size distribution, of microspheres. The conventional microchannel system designs in literature are found poor according to a particular ADT design characteristic called “coupled design.” This paper proposes a “decoupled design” process which is considered better than a “coupled design” process according to ADT. The paper demonstrates the effectiveness of such a “decoupled design” process with a new microchannel system, based on the simulation of the two performance goals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Joscelyne SM, Tragardh G (2000) Membrane emulsification—a literature review. J Membr Sci 169:107–117

    Article  Google Scholar 

  2. Freitas S, Merkle HP, Gander B (2005) Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology. J Control Release 102:313–332

    Article  Google Scholar 

  3. Abrahamse AJ, van Lierop R, van der Sman RGM, van der Padt A, Boom RM (2002) Analysis of droplet formation and interactions during cross-flow membrane emulsification. J Membr Sci 204:125–137

    Article  Google Scholar 

  4. Charcosset C, Limayem I, Fessi H (2004) The membrane emulsification process—a review. J Chem Technol Biotechol 79:209–218

    Article  Google Scholar 

  5. Dendukuri D, Tsoi K, Hatton TA, Doyle PS (2005) Controlled synthesis of nonspherical microparticles using microfluidics. Langmuir 21:2113–2116

    Article  Google Scholar 

  6. Hamouda T, Hayes MM, Cao Z, Tonda R, Johnson K, Wright DC, Brisker J, Baker JR (1999) A novel surfactant nanoemulsion with broad-spectrum sporicidal activity against bacillus species. J Infect Dis 180:1939

    Article  Google Scholar 

  7. Joscelyne SM, Trägårdh G (1999) Food emulsions using membrane emulsification: conditions for producing small droplets. J Food Eng 39:59–64

    Article  Google Scholar 

  8. Schröder V, Behrend O, Schubert H (1998) Effect of dynamic interfacial tension on the emulsification process using microporous, ceramic membranes. J Colloid Interface Sci 202:334–340

    Article  Google Scholar 

  9. Vladisavljevic GT, Schubert H (2002) Preparation and analysis of oil-in-water emulsions with a narrow droplet size distribution using Shirasu-porous-glass (SPG) membranes. Desalination 144:167–172

    Article  Google Scholar 

  10. Wibowo C, Ng KM (2001) Product-oriented process synthesis and development: creams and pastes. AlChE J 47:2746–2767

    Article  Google Scholar 

  11. Williams RA, Peng SJ, Wheeler DA, Morley NC, Taylor D, Whalley M, Houldsworth DW (1998) Controlled production of emulsions using a crossflow membrane part II: industrial scale manufacture. J Chem Eng 76:902–910

    Google Scholar 

  12. Eldridge JH, Staas JK, Meulbroek JA, Tice TR, Gilley RM (1991) Biodegradable and biocompatible poly(DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies. Infect Immun 59:2978–2986

    Google Scholar 

  13. O’Hagan DT, Jeffery H, Davis SS (1993) Long-term antibody responses in mice following subcutaneous immunization with ovalbumin entrapped in biodegradable microparticles. Vaccine 11:965–969

    Article  Google Scholar 

  14. Eldridge JH, Hammond CJ, Meulbroek JA, Staas JK, Gilley RM, Tice TR (1990) Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the Peyer’s patches. J Control Release 11:205–214

    Article  Google Scholar 

  15. Jani P, Halbert GW, Langridge J, Florence AT (1989) The uptake and translocation of latex nanospheres and microspheres after oral administration to rats. J Pharm Pharmacol 41:809

    Article  Google Scholar 

  16. Nisisako T, Torii T, Higuchi T (2002) Droplet formation in a microchannel network. Lab Chip 2:24–26

    Article  Google Scholar 

  17. Guillot P, Colin A (2005) Stability of parallel flows in a microchannel after a T junction. Phys Rev E 72:066301

    Article  Google Scholar 

  18. Thorsen T, Roberts RW, Arnold FH, Quake SR (2001) Dynamic pattern formation in a vesicle-generating microfluidic device. Phys Rev Lett 86:4163–4166

    Article  Google Scholar 

  19. Tice JD, Song H, Lyon AD, Ismagilov RF (2003) Formation of droplets and mixing in multiphase microfluidics at low values of the Reynolds and the capillary numbers. Langmuir 19:9127–9133

    Article  Google Scholar 

  20. van der Graaf S, Steegmans MLJ, van der Sman RGM, Schroen CGPH, Boom RM (2005) Droplet formation in a T-shaped microchannel junction: a model system for membrane emulsification. Colloids Surf Physicochemical Eng Aspects 266:106–116

    Article  Google Scholar 

  21. van der Graaf S, Nisisako T, Schroen CGPH, van der Sman RGM, Boom RM (2006) Lattice Boltzmann simulations of droplet formation in a T-shaped microchannel. Langmuir 22:4144–4152

    Article  Google Scholar 

  22. Shan XW, Chen HD (1993) Lattice Boltzmann model for simulating flows with multiple phases and components. Phys Rev E 47:1815–1819

    Article  Google Scholar 

  23. Swift MR, Orlandini E, Osborn WR, Yeomans JM (1996) Lattice Boltzmann simulations of liquid–gas and binary fluid systems. Phys Rev E 54:5041–5052

    Article  Google Scholar 

  24. Ganan-Calvo AM (1998) Generation of steady liquid microthreads and micron-sized monodisperse sprays in gas streams. Phys Rev Lett 80:285–288

    Article  Google Scholar 

  25. Ganan-Calvo AM, Barrero A (1999) A novel pneumatic technique to generate steady capillary microjets. J Aerosol Sci 30:117–125

    Article  Google Scholar 

  26. Knight JB, Vishwanath A, Brody JP, Austin RH (1998) Hydrodynamic focusing on a silicon chip: mixing nanoliters in microseconds. Phys Rev Lett 80:3863–3866

    Article  Google Scholar 

  27. Kenis PJA, Ismagilov RF, Whitesides GM (1999) Microfabrication inside capillaries using multiphase laminar flow patterning. Science 285:83–85

    Article  Google Scholar 

  28. Anna SL, Bontoux N, Stone HA (2003) Formation of dispersions using “flow focusing” in microchannels. Appl Phys Lett 82:364–366

    Article  Google Scholar 

  29. Engelhardt F (2000) Improving systems by combining axiomatic design, quality control tools and designed experiments. Res Eng Des Theory Appl Concurrent Eng 12:204–219

    Google Scholar 

  30. Suh NP (1998) Axiomatic design theory for systems. Res Eng Des Theory Appl Concurrent Eng 10:189–209

    Google Scholar 

  31. Eppinger SD, Whitney DE, Smith RP, Gebala DA (1994) A model-based method for organizing tasks in product development. Res Eng Des Theory Appl Concurrent Eng 6:1–13

    Google Scholar 

  32. Rechtin E (1992) The art of systems architecting. IEEE Spectr 29:66–69

    Article  Google Scholar 

  33. Suh NP (1990) The principles of design. Oxford University Press, USA

    Google Scholar 

  34. Kannapan SM, Taylor DL (1994) The interplay of context, process, and conflict in concurrent engineering. Concurrent Eng Res Appl 2:183–196

    Article  Google Scholar 

  35. Kim SG, Koo MK (2000) Design of a microactuator array against the coupled nature of microelectromechanical systems (MEMS) processes. CIRP Annals Manuf Tech 450:101–104

    Article  Google Scholar 

  36. Kim SG, Shi Y, Jeon Y (2002) Design of micro-photonic beam steering systems. CIRP Annals Manuf Tech 51:335–338

    Article  Google Scholar 

  37. Hwang KH, Lee KH, Park GJ, Lee BL, Cho YC, Lee SH (2003) Robust design of a vibratory gyroscope with an unbalanced inner torsion gimbal using axiomatic design. J Micromech Microeng 13:8–17

    Article  Google Scholar 

  38. Kreith F (2004) The CRC handbook of mechanical engineering. CRC, Boca Raton

    Google Scholar 

  39. Suh NP (1995) Designing-in of quality through axiomatic design. IEEE Trans Reliab 44:256–264

    Article  Google Scholar 

  40. Suh NP (1992) Design axioms and quality control. Robot Comput-Integr Manuf 9:369–376

    Google Scholar 

  41. Zhao Y, Chen G, Yuan Q (2006) Liquid–liquid two-phase flow patterns in a rectangular microchannel. AlChE J 52:4052–4060

    Article  Google Scholar 

  42. Kobayashi I, Nakajima M, Mukataka S (2003) Preparation characteristics of oil-in-water emulsions using differently charged surfactants in straight-through microchannel emulsification. Colloids Surf Physicochemical Eng Aspects 229:33–41

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to W. J. Zhang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Song, KY., Zhang, W.J. & Gupta, M.M. Incorporation of axiomatic design theory into design of a microchannel system for uniform and size-controllable microspheres. Int J Adv Manuf Technol 57, 491–499 (2011). https://doi.org/10.1007/s00170-011-3324-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00170-011-3324-4

Keywords

Navigation