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Deep learning-based landmark recognition and angle measurement of full-leg plain radiographs can be adopted to assess lower extremity alignment

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Knee Surgery, Sports Traumatology, Arthroscopy Aims and scope

Abstract

Purpose

Evaluating lower extremity alignment using full-leg plain radiographs is an essential step in diagnosis and treatment of patients with knee osteoarthritis. The study objective was to present a deep learning-based anatomical landmark recognition and angle measurement model, using full-leg radiographs, and validate its performance.

Methods

A total of 11,212 full-leg plain radiographs were used to create the model. To train the data, 15 anatomical landmarks were marked by two orthopaedic surgeons. Mechanical lateral distal femoral angle (mLDFA), medial proximal tibial angle (MPTA), joint line convergence angle (JLCA), and hip-knee-ankle angle (HKAA) were then measured. For inter-observer reliability, the inter-observer intraclass correlation coefficient (ICC) was evaluated by comparing measurements from the model, surgeons, and students, to ground truth measurements annotated by an orthopaedic specialist with 14 years of experience. To evaluate test–retest reliability, all measurements were made twice by each measurer. Intra-observer ICCs were then derived. Performance evaluation metrics used in previous studies were also derived for direct comparison of the model’s performance.

Results

Inter-observer ICCs for all angles of the model were 0.98 or higher (p < 0.001). Intra-observer ICCs for all angles were 1.00, which was higher than that of the orthopaedic specialist (0.97–1.00). Measurements made by the model showed no significant systemic variation. Except for JLCA, angles were precisely measured with absolute error averages under 0.52 degrees and proportion of outliers under 4.26%.

Conclusions

The deep learning model is capable of evaluating lower extremity alignment with performance as accurate as an orthopaedic specialist with 14 years of experience.

Level of evidence

III, retrospective cohort study.

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Abbreviations

TKA:

Total knee arthroplasty

OA:

Osteoarthritis

mLDFA:

Mechanical lateral distal femoral angle

MPTA:

Medial proximal tibial angle

JLCA:

Joint line convergence angle

HKAA:

Hip–knee–ankle angle

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Acknowledgements

The authors wish to thank Jeehyeok Chung and Myung Ho Lee providing data for anatomical landmark annotations.

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The article and the submission identify all co-authors who have substantially contributed to the concept, data collection and analysis, or preparation of the manuscript and therefore who may have intellectual property claims to the content. All authors have read and approved the manuscript as submitted and are prepared to take public responsibility for the work.

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Correspondence to Du Hyun Ro.

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The authors certify that they have no commercial association that might pose a conflict of interest in connection with this article.

Ethical approval

This study was approved by Seoul National University Hospital Institutional Review. Board (IRB No. H-1903–170-1018).

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Exemption was approved by Seoul National University Hospital Institutional Review Board.

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Jo, C., Hwang, D., Ko, S. et al. Deep learning-based landmark recognition and angle measurement of full-leg plain radiographs can be adopted to assess lower extremity alignment. Knee Surg Sports Traumatol Arthrosc 31, 1388–1397 (2023). https://doi.org/10.1007/s00167-022-07124-x

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