Abstract
Purpose
To systematically review and critically appraise the literature on double-level osteotomy (DLO) of the knee, and determine the indications, contraindications, targets and outcomes.
Materials and methods
A systematic literature search was performed on PubMed, Embase®, and Cochrane for studies that reported on DLO by any technique or approach, including indications, contraindications, and targets for DLO, as well as patient-reported outcome measures (pROMS) and radiographic angles.
Results
Twelve eligible studies were found: 9 case series and 3 studies that compared DLO to high-tibial osteotomy (HTO). In all studies, DLO was performed by medial opening-wedge tibial osteotomy and lateral closing-wedge femoral osteotomy. Seven specified that DLO was performed if simple HTO would exceed thresholds of postoperative medial proximal tibial angle (MPTA), lateral distal femoral angle (LDFA), and/or predicted wedge size. The targets were 88°–95° for MPTA, 84°–89° for LDFA, and 0°–4° for hip–knee–ankle (HKA) angle. The 3 comparative studies reported lower MPTA after DLO (89.6°–92.5°) than after HTO (91.5°–98.3°). All 3 reported similar postoperative HKA after DLO (0.2°–4.4°) as HTO (0.4°–4.8°); only 2 compared postoperative LDFA, which was lower after DLO (85.4° and 84.9°) than HTO (88.7° and 88.8°). Two comparative studies reported postoperative overall KOOS which was slightly lower after DLO (351–403) than HTO (368–410); only 1 study reported separate items of the KOOS.
Conclusion
There was relative consistency between studies on the indications, targets and techniques for DLO. Furthermore, while the comparative studies reported similar preoperative MPTA, LDFA and HKA, the postoperative MPTA and LDFA were lower after DLO than after HTO, though both treatments achieved equivalent postoperative HKA.
Level of evidence
IV, systematic review.
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References
Akamatsu Y, Nejima S, Tsuji M, Kobayashi H, Muramatsu S (2021) Joint line obliquity was maintained after double-level osteotomy, but was increased after open-wedge high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc. https://doi.org/10.1007/s00167-020-06430-6
Akaoka Y, Iseki T, Kanto R, Onishi S, Tachibana T, Tensho K, Yoshiya S, Nakayama H (2020) Changes in patellar height and patellofemoral alignment following double level osteotomy performed for osteoarthritic knees with severe varus deformity. Asia Pac J Sports Med Arthrosc Rehabil Technol 22:20–26. https://doi.org/10.1016/j.asmart.2020.05.003
Akaoka Y, Nakayama H, Iseki T, Kanto R, Tensho K, Yoshiya S (2020) Postoperative change in patellofemoral alignment following closing-wedge distal femoral osteotomy performed for valgus osteoarthritic knees. Knee Surg Relat Res 32(1):15. https://doi.org/10.1186/s43019-020-00035-6
Babis GC, An KN, Chao EY, Rand JA, Sim FH (2002) Double level osteotomy of the knee: a method to retain joint-line obliquity. Clinical results. J Bone Jt Surg Am 84(8):1380–1388. https://doi.org/10.2106/00004623-200208000-00013
Benjamin A (1969) Double osteotomy for the painful knee in rheumatoid arthritis and osteoarthritis. J Bone Joint Surg Br 51(4):694–699
Chaouche S, Jacquet C, Fabre-Aubrespy M, Sharma A, Argenson JN, Parratte S, Ollivier M (2019) Patient-specific cutting guides for open-wedge high tibial osteotomy: safety and accuracy analysis of a hundred patients continuous cohort. Int Orthop 43(12):2757–2765. https://doi.org/10.1007/s00264-019-04372-4
Grasso F, Martz P, Micicoi G, Khakha R, Kley K, Hanak L, Ollivier M, Jacquet C (2021) Double level knee osteotomy using patient-specific cutting guides is accurate and provides satisfactory clinical results: a prospective analysis of a cohort of twenty-two continuous patients. Int Orthop. https://doi.org/10.1007/s00264-021-05194-z
Hai H, Takahashi I, Shima N, Udono K, Yamaguchi N, Ito A (2020) Preliminary evaluation of the efficacy of postoperative early weight-bearing rehabilitation protocol for patients after double-level osteotomy. Prog Rehabil Med 5:20200017. https://doi.org/10.2490/prm.20200017
Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JA, Cochrane Bias Methods G, Cochrane Statistical Methods G (2011) The Cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ 343:d5928. https://doi.org/10.1136/bmj.d5928
Iseki T, Onishi S, Kanto M, Kanto R, Kambara S, Yoshiya S, Tachibana T, Nakayama H (2021) Double-level osteotomy for severe varus osteoarthritic knees can prevent change in leg length and restore physiological joint geometry. Knee 31:136–143. https://doi.org/10.1016/j.knee.2021.04.011
McInnes MDF, Moher D, Thombs BD, McGrath TA, Bossuyt PM, the P-DTAG, Clifford T, Cohen JF, Deeks JJ, Gatsonis C, Hooft L, Hunt HA, Hyde CJ, Korevaar DA, Leeflang MMG, Macaskill P, Reitsma JB, Rodin R, Rutjes AWS, Salameh JP, Stevens A, Takwoingi Y, Tonelli M, Weeks L, Whiting P, Willis BH (2018) Preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies: the PRISMA-DTA statement. JAMA 319(4):388–396. https://doi.org/10.1001/jama.2017.19163
Nakayama H, Iseki T, Kanto R, Kambara S, Kanto M, Yoshiya S, Schroter S (2020) Physiologic knee joint alignment and orientation can be restored by the minimally invasive double level osteotomy for osteoarthritic knees with severe varus deformity. Knee Surg Sports Traumatol Arthrosc 28(3):742–750. https://doi.org/10.1007/s00167-018-5103-3
Nakayama H, Kanto R, Onishi S, Kambara S, Ukon R, Amai K, Yoshiya S, Schroter S, Tachibana T, Iseki T (2021) Cartilage repair examined by second-look arthroscopy following double-level osteotomy performed for osteoarthritic knees with severe varus deformity. Knee 29:411–417. https://doi.org/10.1016/j.knee.2021.02.024
Nelissen EM, van Langelaan EJ, Nelissen RG (2010) Stability of medial opening wedge high tibial osteotomy: a failure analysis. Int Orthop 34(2):217–223. https://doi.org/10.1007/s00264-009-0723-3
Rupp MC, Muench LN, Ehmann YJ, Themessl A, Winkler PW, Mehl J, Imhoff AB, Feucht MJ (2021) Improved clinical outcome and high rate of return to low impact sport and work after double level osteotomy for bifocal varus malalignment. Arthroscopy. https://doi.org/10.1016/j.arthro.2021.12.004
Saragaglia D, Blaysat M, Mercier N, Grimaldi M (2012) Results of forty two computer-assisted double level osteotomies for severe genu varum deformity. Int Orthop 36(5):999–1003. https://doi.org/10.1007/s00264-011-1363-y
Saragaglia D, Roberts J (2005) Navigated osteotomies around the knee in 170 patients with osteoarthritis secondary to genu varum. Orthopedics 28(10 Suppl):s1269-1274. https://doi.org/10.3928/0147-7447-20051002-13
Schroter S, Nakayama H, Yoshiya S, Stockle U, Ateschrang A, Gruhn J (2019) Development of the double level osteotomy in severe varus osteoarthritis showed good outcome by preventing oblique joint line. Arch Orthop Trauma Surg 139(4):519–527. https://doi.org/10.1007/s00402-018-3068-9
Yang JC, Chen CF, Luo CA, Chang MC, Lee OK, Huang Y, Lin SC (2018) Clinical experience using a 3D-printed patient-specific instrument for medial opening wedge high tibial osteotomy. Biomed Res Int 2018:9246529. https://doi.org/10.1155/2018/9246529
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This article was funded by Fondation de la Tour pour la recherche et l’enseignement.
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This study involved no human or animal subjects as it based on published literature; Its protocol including the search strategy was registered on PROSPERO (CRD42021278652).
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Alves, P., van Rooij, F., Kuratle, T. et al. Consistent indications, targets and techniques for double-level osteotomy of the knee: a systematic review. Knee Surg Sports Traumatol Arthrosc 30, 4078–4087 (2022). https://doi.org/10.1007/s00167-022-06915-6
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DOI: https://doi.org/10.1007/s00167-022-06915-6