Knee Surgery, Sports Traumatology, Arthroscopy

, Volume 25, Issue 10, pp 3319–3325 | Cite as

Does platelet-rich plasma decrease time to return to sports in acute muscle tear? A randomized controlled trial

  • Luciano Andrés Rossi
  • Agustín Rubén Molina RómoliEmail author
  • Bernardo Agustín Bertona Altieri
  • Jose Aurelio Burgos Flor
  • Walter Edgardo Scordo
  • Cristina María Elizondo
Sports Medicine



The aim of this study is to report the effects of autologous PRP injections on time to return to play and recurrence rate after acute grade 2 muscle injuries in recreational and competitive athletes.


Seventy-five patients diagnosed with acute muscle injuries were randomly allocated to autologous PRP therapy combined with a rehabilitation programme or a rehabilitation programme only. The primary outcome of this study was time to return to play. In addition, changes in pain severity and recurrence rates were evaluated.


Patients in the PRP group achieved full recovery significantly earlier than controls (P = 0.001). The mean time to return to play was 21.1 ± 3.1 days and 25 ± 2.8 days for the PRP and control groups, respectively (P = 0.001). Significantly lower pain severity scores were observed in the PRP group throughout the study. The difference in the recurrence rate after 2-year-follow-up was not statistically significant between groups.


A single PRP injection combined with a rehabilitation programme significantly shortened time to return to sports compared to a rehabilitation programme only. Recurrence rate was not significantly different between groups.

Level of evidence



Platelet-rich plasma Acute muscle injuries Return to sports 



This study was approved by the Ethical committee of the Italian Hospital from Buenos Aires. IRB: 00003580, study protocol number 1772.


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Copyright information

© European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2016

Authors and Affiliations

  • Luciano Andrés Rossi
    • 1
  • Agustín Rubén Molina Rómoli
    • 1
    Email author
  • Bernardo Agustín Bertona Altieri
    • 1
  • Jose Aurelio Burgos Flor
    • 1
  • Walter Edgardo Scordo
    • 1
  • Cristina María Elizondo
    • 1
  1. 1.Italian Hospital from Buenos AiresBuenos AiresArgentina

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