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Meniscal allograft transplantation in a symptomatic meniscal deficient knee: a systematic review

Knee Surgery, Sports Traumatology, Arthroscopy volume 23, pages 270–279 (2015)Cite this article

Abstract

Purpose

The primary objective of this study was to perform an updated systematic review and meta-analysis of meniscal allograft transplantation using patient reported outcome measures at final follow-up as the outcome tool. The secondary objective was to provide an up to date review of the indications, associated procedures, operative technique, rehabilitation, failures, complications, radiological outcomes, and graft healing.

Methods

Medline, Embase and CENTRAL databases, trials registries, and Web-of Science were searched for studies using pre-defined eligibility criteria. Included studies were reviewed with Lysholm, International Knee Documentation Committee (IKDC) and Tegner scores, failures and complications pooled. Studies were also qualitatively assessed.

Results

There were 1,332 patients (1,374 knees) in 35 studies eligible for analysis. The mean follow-up was 5.1 years. Across all studies, Lysholm scores improved from 55.7 to 81.3, IKDC scores from 47.0 to 70.0, and Tegner activity scores from 3.1 to 4.7 between pre-operative and final follow-up assessments, respectively. The mean failure rate across all studies was 10.6 % at 4.8 years, and complication rate was 13.9 % at 4.7 years. There is a high risk of bias across the studies due to study design and missing outcomes.

Conclusion

Based on current evidence, meniscal allograft transplantation appears to be an effective intervention for patients with a symptomatic meniscal deficient knee. This should ideally be confirmed with a randomised controlled trial. There is not currently enough evidence to determine whether it is chondroprotective.

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Acknowledgments

This work was supported by Arthritis Research UK (Grant Number 20149).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

This study does not contain new patient data.

Author information

Affiliations

  1. Clinical Sciences Research Laboratories, University of Warwick, Clifford Bridge Road, Coventry, CV2 2DX, UK

    Nick A. Smith

  2. Western Infirmary Glasgow, Dumbarton Road, Glasgow, G11 6NT, UK

    Nicola MacKay

  3. Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK

    Matthew Costa

  4. University Hospitals Coventry and Warwickshire, 5th floor UHCW, Clifford Bridge Road, Coventry, CV2 2DX, UK

    Tim Spalding

Authors
  1. Nick A. Smith
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  2. Nicola MacKay
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  3. Matthew Costa
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  4. Tim Spalding
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Correspondence to Nick A. Smith.

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Smith, N.A., MacKay, N., Costa, M. et al. Meniscal allograft transplantation in a symptomatic meniscal deficient knee: a systematic review. Knee Surg Sports Traumatol Arthrosc 23, 270–279 (2015). https://doi.org/10.1007/s00167-014-3310-0

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  • DOI: https://doi.org/10.1007/s00167-014-3310-0

Keywords

  • Meniscal allograft transplantation
  • Systematic review
  • Meniscectomy
  • Patient reported outcome measures