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Efficacy of intraarticular application of ketamine or ketamine–levobupivacaine combination on post-operative pain after arthroscopic meniscectomy

  • Knee
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Knee Surgery, Sports Traumatology, Arthroscopy Aims and scope

An Erratum to this article was published on 31 August 2014

Abstract

Purpose

To evaluate the efficacy of intraarticular injection of ketamine or ketamine plus levobupivacaine on post-operative analgesia in patients undergoing arthroscopic meniscectomy.

Methods

A prospective, randomized, double-blind study was performed on 60 patients aged 18–65 years who planned to undergo elective arthroscopic meniscectomy. The patients were divided into three groups: the ketamine group (n = 20) received 1.0 mg/kg of intraarticular ketamine in 20 ml of normal saline, the ketamine–levobupivacaine group (n = 20) received 0.5 mg/kg of intraarticular ketamine plus 50.0 mg of 0.25 % levobupivacaine in 20 ml of normal saline, and the control group (n = 20) received 20 ml of intraarticular normal saline. A visual analogue scale (VAS) was used to determine the efficacy of analgesia at 1, 2, 4, 6, 8, 12, and 24 h post-operatively.

Results

There were statistically significant differences in the median VAS scores among the three groups according to Bonferroni adjustment at all time points (p < 0.01), with the exception of 6 and 24 h post-operatively. The median VAS scores at 1, 2, and 4 h post-operatively were higher in the control group than in the two treatment groups (p < 0.001). The median VAS scores in the control group at 1, 2, 4, 6, 8, and 12 h post-operatively and those in the ketamine group at 4, 8, and 12 h post-operatively were significantly higher than those in the ketamine–levobupivacaine group (p < 0.05).

Conclusion

Intraarticular ketamine provides effective post-operative analgesia. Addition of intraarticular levobupivacaine to ketamine may provide better amelioration of pain after outpatient arthroscopic meniscectomy.

Level of evidence

I.

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Authors and Affiliations

  1. Department of Orthopedics and Traumatology, Faculty of Medicine, Abant İzzet Baysal University Medical School, Abant İzzet Baysal University, 14280, Gölköy, Bolu, Turkey

    Cengiz Isik & Hakan Sarman

  2. Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey

    Abdullah Demirhan & Umit Yasar Tekelioglu

  3. Department of Orthopedics and Traumatology, Bolu Izzet Baysal State Hospital, Bolu, Turkey

    Tevfik Yetis & Turan Duran

  4. Department of Anesthesiology and Reanimation, Bolu Izzet Baysal State Hospital, Bolu, Turkey

    Korgun Oktem

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  1. Cengiz Isik
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  2. Abdullah Demirhan
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  3. Tevfik Yetis
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  4. Korgun Oktem
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Correspondence to Cengiz Isik.

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Isik, C., Demirhan, A., Yetis, T. et al. Efficacy of intraarticular application of ketamine or ketamine–levobupivacaine combination on post-operative pain after arthroscopic meniscectomy. Knee Surg Sports Traumatol Arthrosc 23, 2721–2726 (2015). https://doi.org/10.1007/s00167-014-2962-0

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