Abstract
The performance of serum cystatin C as a screening marker of reduced creatinine clearance in renal transplantation was evaluated and compared to serum creatinine. In addition we studied whether cystatin C accurately reflects creatinine clearance over the entire range of transplant function. Serum cystatin C, serum creatinine, and creatinine clearance were measured in 110 adult renal transplant recipients. Cystatin C detected reduced creatinine clearance with the high sensitivity of 95 %. Serum cystatin C and serum creatinine did not differ regarding 90 and 95 % sensitivity, derived from the receiver-operating characteristics plot. We demonstrated a strong correlation and linear association between 1/cystatin C and creatinine clearance over the entire range of transplant function, equivalent to that of 1/creatinine. In summary, serum cystatin C accurately reflects creatinine clearance over the entire range of transplant function and is as efficacious as serum creatinine to detect reduced creatinine clearance in renal transplant recipients.
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Received: 5 June 1999 Revised: 8 March 2000 Accepted: 20 April 2000
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Herget-Rosenthal, S., Trabold, S., Huesing, J. et al. Cystatin C – an accurate marker of glomerular filtration rate after renal transplantation?. Transpl Int 13, 285–289 (2000). https://doi.org/10.1007/s001470050703
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DOI: https://doi.org/10.1007/s001470050703