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Systematic evaluation of distribution of transgene expression after adenovirus-mediated gene transfer to the transplanted heart

  • ORIGINAL ARTICLE
  • Published:
Transplant International

Abstract

In the transplantation setting, the study and potential treatment of acute and chronic rejection by means of gene therapy will require widespread transgene expression in the donor organ. The distribution of transgene expression after adenovirus-mediated gene transfer via the coronary vasculature in a model of abdominal heterotopic heart transplantation in syngeneic rats (n = 6) was evaluated at 1 week. Reporter gene expression was evenly distributed in the base, the midventricle, and the apex of the transplanted hearts. This study demonstrates that intracoronary administration of the adenoviral vector to the donor heart results in widespread transgene expres- sion.

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Authors and Affiliations

  1. Department of Surgery, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA Fax: + 1 507 255 4500, , , , , , US

    Carlo Pellegrini, John Yap, Anders Jeppsson & C. G. A. McGregor

  2. Department of Endocrinology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA, , , , , , US

    Timothy O'Brien

  3. Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA, , , , , , US

    Henry D. Tazelaar

Authors
  1. Carlo Pellegrini
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  2. Timothy O'Brien
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  3. John Yap
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  4. Anders Jeppsson
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  5. Henry D. Tazelaar
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  6. C. G. A. McGregor
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Additional information

Received: 9 December 1997 Received after revision: 24 March 1998 Accepted: 15 April 1998

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Pellegrini, C., O'Brien, T., Yap, J. et al. Systematic evaluation of distribution of transgene expression after adenovirus-mediated gene transfer to the transplanted heart. Transpl Int 11, 373–377 (1998). https://doi.org/10.1007/s001470050160

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  • DOI: https://doi.org/10.1007/s001470050160

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