Abstract
Serum levels of interleukin-8 (IL-8) were investigated in the perioperative phase of liver transplantation (LTx) in order to help determine whether this cytokine might serve as a parameter for preservation injury. In a study of 45 patients undergoing LTx, systemic IL-8 was estimated at the end of the anhepatic phase, at 30, 60, and 120 min after reperfusion of the graft, and 24 h and 7 days after LTx. A maximum mean concentration of 665 ± 135 pg/ml was seen 60 min after LTx. The minimum was found on the 1st postoperative day (POD 1): 328 ± 33 pg/ml. Significant changes were found between 60 min and PODs 1 and 7, as well as between 120 min and POD 1. Differences in cold ischemia time were not found to be significant. We conclude that monitoring of systemic IL-8 levels is not useful in the development of new liver preservation concepts.
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Received: 12 September 1996 Received after revision: 27 February 1997 Accepted: 3 March 1997
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Gerlach, J., Jörres, A., Schön, M. et al. Systemic liberation of interleukin-8 in the perioperative phase of liver transplantation. Transpl Int 10, 401–404 (1997). https://doi.org/10.1007/s001470050079
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DOI: https://doi.org/10.1007/s001470050079