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Involvement of tumor necrosis factor-α receptor 1 and tumor necrosis factor-related apoptosis-inducing ligand-(TRAIL) receptor-2/DR-5, but not Fas, in graft injury in live-donor liver transplantation

  • Original Article
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Transplant International

Abstract

The pathway leading to cell death in clinical liver transplantation is not known. Eight liver transplant recipients and eight donors were enrolled in this study. Postoperative serum levels of alanine transferase had significantly increased in the recipients compared with those in the donors. Mild centri-lobular necrosis was observed in only liver tissues taken from the recipients. Tumor necrosis factor (TNF)-R1 and death receptor 5 expression levels had increased in liver tissues taken from the recipients. There were no changes in the levels of Fas/Fas ligand expression in liver tissues from either the donors or recipients. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression was down-regulated in donor liver after hepatectomy and liver allograft after implantation. The results suggest that, although ischemic liver injury was not serious, due to the short ischemia time, TNF and TRAIL signals are associated with liver ischemic injury in live-donor liver transplantation but Fas signal is not

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Acknowledgments

The authors thank Yuka Tanaka for expert secretarial assistance.

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Authors and Affiliations

  1. Second Department of Surgery, Faculty of Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734–8551, Hiroshima, Japan

    Hirotaka Tashiro, Toshiyuki Itamoto, Hideki Ohdan, Hideki Nakahara, Makoto Ochi, Hiroshi Hino, Kazuyuki Mizunuma, Hidetaka Hara, Daisuke Tokita, Takashi Onoe, Kouhei Ishiyama, Hiroshi Mitsuta, Keizou Sugino & Toshimasa Asahara

  2. Department of Pathology, Hiroshima University Hospital, Hiroshima, Japan

    Kouji Arihiro

  3. Laboratory of Developmental Biology, Department of Biological Science, Graduate School of Science, Hiroshima University, Hiroshima, Japan

    Yuko Tateaki

Authors
  1. Hirotaka Tashiro
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  2. Toshiyuki Itamoto
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Correspondence to Hirotaka Tashiro.

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Tashiro, H., Itamoto, T., Ohdan, H. et al. Involvement of tumor necrosis factor-α receptor 1 and tumor necrosis factor-related apoptosis-inducing ligand-(TRAIL) receptor-2/DR-5, but not Fas, in graft injury in live-donor liver transplantation. Transpl Int 17, 626–633 (2004). https://doi.org/10.1007/s00147-004-0762-z

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  • DOI: https://doi.org/10.1007/s00147-004-0762-z

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