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Grundlagen biologischer Augmentationstechniken

Vom Wachstumsfaktor bis zur Stammzelle

Biologics in orthopaedic surgery

From growth factors to stem cell application

  • Leitthema
  • Published:
Arthroskopie Aims and scope

Zusammenfassung

Hintergrund

Der Heilungsprozess von Geweben ist ein höchst komplexer Vorgang. Die primären biomechanischen Qualitäten von orthopädischen Rekonstruktionstechniken konnten in den letzten Jahren zwar sukzessive weiterentwickelt werden, die Einheilung erfolgt jedoch häufig durch die Produktion von biomechanisch minderwertigem Narbengewebe. Daher ist die Versagensquote nach wie vor erhöht. Biologische Augmentationen, z. B. durch Wachstumsfaktoren, Plasmakonzentrate oder Zellen, sind vielversprechende Ansätze, um die Heilungsverläufe zu beschleunigen, eine verbesserte Qualität des Gewebes zu erzeugen oder auch Gewebsdefekte zu überbrücken.

Ergebnisse

Die meisten biologischen Augmentationstechniken befinden sich noch im experimentellen Stadium, so dass ihre Effekte in der klinischen Anwendung noch nicht abschließend beurteilt werden können.

Schlussfolgerung

Dieser Artikel soll einen kurzen Überblick über die Grundlagen der unterschiedlichen biologischen Augmentationsverfahren bieten.

Abstract

Background

The healing process of tissue is very complex. The primary biomechanical qualities of orthopedic reconstruction techniques have been successively improved in recent years, but the healing process often results in the production of biomechanically inferior scar tissue, leading to an increased failure rate. Biological augmentation, such as with growth factors, plasma concentrates or cells represent promising approaches to accelerate healing processes, to produce improved quality of reconstructed tissue and to reconstruct larger tissue defects.

Results

Most of these techniques are still in the experimental stage. Therefore, their effects in clinical practice cannot yet be finally assessed.

Conclusion

This article provides a brief overview of the basic principles of some of these biological augmentation methods.

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Interessenkonflikt

Der korrespondierende Autor gibt für sich und seinen Koautor folgende Beziehungen an: Das University of Connecticut/New England Musculoskeletal Institute erhält direkte finanzielle und materielle Forschungsunterstützung von Arthrex Inc. (Naples, USA). Dr. Mazzocca erhält direkte Forschungsunterstützung und ist ein Berater für Arthrex Inc.

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Authors and Affiliations

  1. Abteilung für Trauma und Orthopädische Chirurgie, Berufsgenossenschaftliche Unfallklinik Murnau, Professor-Küntscher-Str. 8, 82418, Murnau am Staffelsee, Deutschland

    K. Beitzel M.A.

  2. Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, USA

    A.D. Mazzocca

  3. Argon Orthopädie, Hamburg, Deutschland

    W. Siekmann

  4. Abteilung für Sportorthopädie, Klinikum rechts der Isar der TU München, München, Deutschland

    A. Schmitt

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  1. K. Beitzel M.A.
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  2. A.D. Mazzocca
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  3. W. Siekmann
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  4. A. Schmitt
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Correspondence to K. Beitzel M.A..

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Beitzel, K., Mazzocca, A., Siekmann, W. et al. Grundlagen biologischer Augmentationstechniken. Arthroskopie 26, 91–98 (2013). https://doi.org/10.1007/s00142-012-0734-8

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  • DOI: https://doi.org/10.1007/s00142-012-0734-8

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