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Matrixassoziierte Chondrozytentransplantation — Biomateralien in der Knorpelzelltransplantation

Matrix associated chondrocyte transplantation — biomaterials in cartilage repair

  • Leitthema
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Arthroskopie Aims and scope

Zusammenfassung

Die autologe Chondrozytentransplantation hat die Behandlung von Knorpeldefekten revolutioniert. In der ursprünglichen Operationstechnik wird der debredierte Defekt mit einem Periostlappen verschlossen, und Chondrozyten in Suspension werden injiziert. Diese Technik hat jedoch einige Nachteile wie Probleme bei der Gewinnung und Befestigung des Periostlappens und Tendenzen zu Hypertrophie und Delamination des Lappens. Mit der Entwicklung von Biomaterialien wurde es möglich, ein sicheres und verlässliches Zelltransportsystem zuschaffen, das darüber hinaus auch die Neubildung von Gewebe begünstigt. Biomaterialien werden intensiv beforscht und sind bereits vielfach in klinischer Anwendung. Die vielversprechenden Ergebnisse dieser neuen Techniken erweitern die Indikationen der zellbasierten Knorpeltherapie und deuten neue Wege für regenerative Knorpelbehandlung an.

Abstract

Autologous chondrocyte transplantation has revolutionized treatment options in cartilage defects in the last decade. The classic technique with the periosteal flap has some disadvantages regarding the periost harvest and fixation, as well as the varying biological properties of the periosteal tissue leading to hypertrophy and delamination of the graft impairing the clinical result. The development of biomaterials as a scaffold for cell transplantation allows a secure and reliable transport of the cells to the defect site to facilitate cartilage formation. Emerging research on the biomaterials has developed various kinds of materials, of which some are already in clinical use. The promising results of the new techniques will widen the indications for such methods and open the way for a new paradigm in cartilage treatment from repair to regeneration.

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  1. Orthopädische Abteilung, Medizinische Universität des AKH Wien

    S. Nehrer, P. Vavken, R. Dorotka & R. Kotz

  2. Orthopädische Abteilung, Medizinische Universität des AKH, Währinger Gürtel 18–20, 1090 , Wien, Österreich

    S. Nehrer

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  1. S. Nehrer
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  4. R. Kotz
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Correspondence to S. Nehrer.

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Nehrer, S., Vavken, P., Dorotka, R. et al. Matrixassoziierte Chondrozytentransplantation — Biomateralien in der Knorpelzelltransplantation. Arthroskopie 18, 203–208 (2005). https://doi.org/10.1007/s00142-005-0325-z

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  • DOI: https://doi.org/10.1007/s00142-005-0325-z

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