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Autologe Chondrozytentransplantation mit arthroskopischer Technik

Autologous chondrocyte transplantation using an arthroscopic technique

  • Leitthema
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Arthroskopie Aims and scope

Zusammenfassung

Zur arthroskopischen autologen Chondrozytentransplantation wurde ein biologisch abbaubares, biokompatibles Gerüst auf der Basis von Hyaluronsäure verwendet. Alle Patienten wurden nach dem Score der International Repair Cartilage Society prospektiv evaluiert. Die Studie analysiert die klinischen Ergebnisse bei arthroskopisch behandelten Patienten mit 24-monatiger Nachbeobachtung.

Während der Behandlungs- und Nachbeobachtungszeit kam es weder zu Komplikationen aufgrund des Implantats noch zu schweren Nebenwirkungen. Nach 12 Monaten verbesserten sich objektiver als auch subjektiver IKDC-Score statistisch signifikant. Es ergab sich kein statistisch signifikanter Unterschied zwischen den klinischen Ergebnissen nach 12 und 24 Monaten.

Dieses Verfahren der autologen Chondrozytentransplantation mit Matrix vereinfacht die Operation und ermöglicht eine arthroskopische Implantation mit reduzierter Operationsmorbidität und Erholungszeit für den Patienten.

Abstract

A biodegradable, hyaluronan-based biocompatible scaffold was used for autologous chondrocyte transplantation using an arthroscopic technique. All patients were prospectively evaluated according to the International Repair Cartilage Society score. This study analyzed the clinical outcome of patients treated by arthroscopic technique during a 24-month follow-up period.

No complications related to the implant and no serious adverse events were observed during the treatment and follow-up period. Statistically significant improvement of IKDC objective and subjective scores was observed just at 12 months. There was no statistically significant difference between clinical results after 12 and 24 months.

This matrix autologous chondrocyte transplantation technique simplifies the surgical procedure and permits arthroscopic implantation, thus reducing the surgical morbidity and the recovery time for the patient.

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Danksagung

Dr. S. Bassini für die Abbildungen, Dr. A. Montaperto, Dr. A. Visani, M. Bonfiglioli (biomechanisches Labor, Orthopädisches Institut Rizzoli, Bologna, Italien)

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Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.

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Authors and Affiliations

  1. Laboratorio di Biomeccanica, Istituti Ortopedici Rizzoli, Bologna/Italien

    M. Marcacci,  E. Kon, L. Marchesini, F. Iacono & S. Zaffagnini

  2. Laboratorio di Biomeccanica, Istituti Ortopedici Rizzoli, Via Di Barbiano 1/10, 40136 , Bologna, Italien

    E. Kon

Authors
  1. M. Marcacci
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  2. E. Kon
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  3. L. Marchesini
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  4. F. Iacono
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  5. S. Zaffagnini
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Correspondence to E. Kon.

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Marcacci, M., Kon, E., Marchesini, L. et al. Autologe Chondrozytentransplantation mit arthroskopischer Technik. Arthroskopie 18, 213–218 (2005). https://doi.org/10.1007/s00142-005-0324-0

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  • DOI: https://doi.org/10.1007/s00142-005-0324-0

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