Skip to main content

Susceptibility to critical illness: reserve, response and therapy


Risk of critical illness is determined both by genetic and environmental influences, particularly those relating to infectious and cardiovascular diseases. Physiologically-based scoring systems cannot measure prior risk because they do not quantify physiological reserve independently of the acute illness. Genetic profiling could be useful for risk assessment. Early detection of critical illness involves identifying physiological ’triggers' for referral; this requires the education of nursing and medical staff in their significance. Analysis of the relationship between risk factors and interventions may need complex modelling techniques. Therapeutic strategies depend on the nature of the underlying problem: the most useful are likely to be those which enhance tissue oxygen delivery and resistance to infection.

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bion, J. Susceptibility to critical illness: reserve, response and therapy. Intensive Care Med 26, S057–S063 (2000).

Download citation

  • Issue Date:

  • DOI:

  • Key words Critical illness
  • Intensive care
  • Severity of illness
  • Scoring systems
  • Genetics
  • Susceptibility
  • Education