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Effects of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green in human septic shock

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Abstract

Objectives: To evaluate the effect of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green (PDR) in patients with septic shock.

Design and setting: A prospective clinical study in a university hospital intensive care unit.

Patients and interventions: 20 patients in septic shock. Patients received iloprost infusion (1 ng/kg per minute) for 24 h.

Measurements and results: PDR was determined by a femoral arterial fiberoptic catheter before, 1, 6, and 24 h after start and 1 h after end of iloprost infusion. PDR increased significantly 24 h after start of iloprost infusion (baseline: 13.9±1.7% vs. 18.6±2.2%/min) and decreased 1 h after end of infusion (13.7±1.7%/min; p<0.002). There was no change in pHi, cardiac index, mean arterial pressure, heart rate, central venous pressure, or intrathoracic blood volume index.

Conclusion: Administration of the stable prostacyclin analogue iloprost significantly increases PDR, indicating improvement in liver function.

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Final revision received: 28 July 2000

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Lehmann, C., Taymoorian, K., Wauer, H. et al. Effects of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green in human septic shock. Intensive Care Med 26, 1557–1560 (2000). https://doi.org/10.1007/s001340000662

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  • DOI: https://doi.org/10.1007/s001340000662

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