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Ten tips on sepsis-induced thrombocytopenia

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References

  1. Huebsh LB, Harker LA (1981) Disorders of platelet function - mechanisms, diagnosis and management. West J Med 134:109–127. https://doi.org/10.1001/jama.1886.04250120041003

    Article  Google Scholar 

  2. Jonsson AB, Rygård SL, Hildebrandt T et al (2021) Thrombocytopenia in intensive care unit patients: a scoping review. Acta Anaesthesiol Scand 65:2–14. https://doi.org/10.1111/aas.13699

    Article  PubMed  Google Scholar 

  3. Anthon CT, Pène F, Perner A et al (2023) Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU). Intensive Care Med 49:1327–1338. https://doi.org/10.1007/s00134-023-07225-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Péju E, Fouqué G, Charpentier J et al (2023) Clinical significance of thrombocytopenia in patients with septic shock: an observational retrospective study. J Crit Care 76:154293. https://doi.org/10.1016/j.jcrc.2023.154293

    Article  CAS  PubMed  Google Scholar 

  5. Koyama K, Katayama S, Muronoi T et al (2018) Time course of immature platelet count and its relation to thrombocytopenia and mortality in patients with sepsis. PLoS ONE 13:1–16. https://doi.org/10.1371/journal.pone.0192064

    Article  CAS  Google Scholar 

  6. Thiolliere F, Serre-Sapin AF, Reignier J et al (2013) Epidemiology and outcome of thrombocytopenic patients in the intensive care unit: results of a prospective multicenter study. Intensive Care Med 39:1460–1468. https://doi.org/10.1007/s00134-013-2963-3

    Article  PubMed  Google Scholar 

  7. Claushuis TAM, Van Vught LA, Scicluna BP et al (2016) Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients. Blood 127:3062–3072. https://doi.org/10.1182/blood-2015-11-680744

    Article  CAS  PubMed  Google Scholar 

  8. Clark SR, Ma AC, Tavener SA et al (2007) Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 13:463–469. https://doi.org/10.1038/nm1565

    Article  CAS  PubMed  Google Scholar 

  9. Ho-Tin-Noé B, Demers M, Wagner DD (2011) How platelets safeguard vascular integrity. J Thromb Haemost 9:56–65. https://doi.org/10.1111/j.1538-7836.2011.04317.x

    Article  PubMed  PubMed Central  Google Scholar 

  10. Iba T, Levy JH, Wada H et al (2019) Differential diagnoses for sepsis-induced disseminated intravascular coagulation: communication from the SSC of the ISTH. J Thromb Haemost 17:415–419. https://doi.org/10.1111/jth.14354

    Article  CAS  PubMed  Google Scholar 

  11. Scharf RE (2012) Drugs that affect platelet function. Semin Thromb Hemost 38:865–883. https://doi.org/10.1055/s-0032-1328881

    Article  CAS  PubMed  Google Scholar 

  12. Marini I, Uzun G, Jamal K, Bakchoul T (2022) Treatment of drug-induced immune thrombocytopenias. Haematologica 107:1264–1277. https://doi.org/10.3324/haematol.2021.279484

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Russell L, Holst LB, Kjeldsen L et al (2017) Risks of bleeding and thrombosis in intensive care unit patients with haematological malignancies. Ann Intensive Care 7:119. https://doi.org/10.1186/s13613-017-0341-y

    Article  PubMed  PubMed Central  Google Scholar 

  14. Carini FC, Angriman F, Scales DC et al (2024) Venous thromboembolism in critically ill adult patients with hematologic malignancy: a population-based cohort study. Intensive Care Med 50:222–233. https://doi.org/10.1007/s00134-023-07287-2

    Article  PubMed  Google Scholar 

  15. Wu S, Chen Q, Pan J, Zhou A (2022) Platelet transfusion and mortality in patients with sepsis-induced thrombocytopenia: a propensity score matching analysis. Vox Sang 117:1187–1194. https://doi.org/10.1111/vox.13335

    Article  CAS  PubMed  Google Scholar 

  16. van Baarle F, van de Weerdt EK, van der Velden WJFM et al (2023) Platelet transfusion before cvc placement in patients with thrombocytopenia. N Engl J Med 388:1956–1965. https://doi.org/10.1056/NEJMoa2214322

    Article  PubMed  Google Scholar 

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Correspondence to Marc Leone.

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ML served as speaker for Shionogi and consultant for AOP Pharma and Viatris. NDN serves on advisory boards for Inotrem and Adrenomed. LR has no conflict of interest to disclose.

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Leone, M., Nielsen, N.D. & Russell, L. Ten tips on sepsis-induced thrombocytopenia. Intensive Care Med (2024). https://doi.org/10.1007/s00134-024-07478-5

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