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Failure of target attainment for beta-lactam antibiotics and ciprofloxacin in acute brain-injured intensive care patients

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Fig. 1

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The data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We thank I. M. Purmer and P. van Vliet for their contribution in revising and improving the manuscript.

Funding

The main DOLPHIN trial received funding from the Dutch Organization for Health Research and Development ZonMw (Grant 848017008), Stichting de Merel and Erasmus MC MRace Grant. The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The Phd program of SE is funded by the Dutch brain foundation, which did not influence the process of writing this manuscript.

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Authors and Affiliations

  1. Department of Intensive Care Adults, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands

    Saliha Ergezen, Tim M. J. Ewoldt, Mathieu van der Jagt & Henrik Endeman

  2. Department of Neurosurgery, Erasmus University Medical Center, Rotterdam, The Netherlands

    Saliha Ergezen

  3. Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands

    Tim M. J. Ewoldt & Birgit C. P. Koch

  4. Rotterdam Clinical Pharmacometrics Group, Rotterdam, The Netherlands

    Tim M. J. Ewoldt & Birgit C. P. Koch

Authors
  1. Saliha Ergezen
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  2. Tim M. J. Ewoldt
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  3. Mathieu van der Jagt
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  4. Birgit C. P. Koch
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  5. Henrik Endeman
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Consortia

the DOLPHIN Investigators

Contributions

Statistical analysis was performed by TMJE with input of SE. The first draft of the manuscript was written by SE and further improved based on the suggestions of TMJE, MvdJ, BCPK, HE, IMP and PvV. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Saliha Ergezen.

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Conflicts of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethics approval and consent to participate

Medical ethical board approval for the DOLPHIN trial was obtained at the Erasmus University Medical Center (Erasmus MC) (MEC-2017–568; EudraCT 2017–004677-14). Written informed consent was obtained from all patients or their legal representatives before randomization.

Consent for publication

In the DOLPHIN trial, written informed consent was obtained from all patients or their legal representatives before randomization.

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Ergezen, S., Ewoldt, T.M.J., van der Jagt, M. et al. Failure of target attainment for beta-lactam antibiotics and ciprofloxacin in acute brain-injured intensive care patients. Intensive Care Med (2024). https://doi.org/10.1007/s00134-024-07459-8

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