Skip to main content
SpringerLink
Log in

Factors associated with successful liberation from continuous renal replacement therapy in children and young adults: analysis of the worldwide exploration of renal replacement outcomes collaborative in Kidney Disease Registry

  • Original
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

Abstract

Purpose

Continuous renal replacement therapy (CRRT) is used for supportive management of acute kidney injury (AKI) and disorders of fluid balance (FB). Little is known about the predictors of successful liberation in children and young adults. We aimed to identify the factors associated with successful CRRT liberation.

Methods

The Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease study is an international multicenter retrospective study (32 centers, 7 nations) conducted from 2015 to 2021 in children and young adults (aged 0–25 years) treated with CRRT for AKI or FB disorders. Patients with previous dialysis dependence, tandem extracorporeal membrane oxygenation use, died within the first 72 h of CRRT initiation, and those who never had liberation attempted were excluded. Patients were categorized based on first liberation attempt: reinstituted (resumption of any dialysis within 72 h) vs. success (no receipt of dialysis for ≥ 72 h). Multivariable logistic regression was used to identify factors associated with successful CRRT liberation.

Results

A total of 622 patients were included: 287 (46%) had CRRT reinstituted and 335 (54%) were successfully liberated. After adjusting for sepsis at admission and illness severity parameters, several factors were associated with successful liberation, including higher VIS (vasoactive–inotropic score) at CRRT initiation (odds ratio [OR] 1.35 [1.12–1.63]), higher PELOD-2 (pediatric logistic organ dysfunction-2) score at CRRT initiation (OR 1.71 [1.24–2.35]), higher urine output prior to CRRT initiation (OR 1.15 [1.001–1.32]), and shorter CRRT duration (OR 0.19 [0.12–0.28]).

Conclusions

Inability to liberate from CRRT was common in this multinational retrospective study. Modifiable and non-modifiable factors were associated with successful liberation. These results may inform the design of future clinical trials to optimize likelihood of CRRT liberation success.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Data availability

De‐identified summary data are available through the WE-ROCK collaborative. Data dictionaries, in addition to study protocol, the statistical analysis plan will be made available upon request. More information about the process and available data can be obtained by contacting the corresponding author (EKS). The data from the WE-ROCK collaborative will be made available to researchers who provide a methodologically sound proposal for use in achieving the goals of the approved proposal following an application process and execution of a data-use agreement as required by the Institutional Review Board at the Cincinnati Children’s Hospital Medical as part of the approval of this collaborative study.

References

  1. Kaddourah A, Basu RK, Bagshaw SM, Goldstein SL (2017) Epidemiology of acute kidney injury in critically ill children and young adults. N Engl J Med 376(1):11–20. https://doi.org/10.1056/NEJMoa1611391

    Article  PubMed  Google Scholar 

  2. Wieczorek B, Ascenzi J, Kim Y et al (2016) PICU up!: Impact of a quality improvement intervention to promote early mobilization in critically ill children. Pediatr Crit Care Med 17(12):e559–e566. https://doi.org/10.1097/pcc.0000000000000983

    Article  PubMed  PubMed Central  Google Scholar 

  3. Li L, Li X, Xia Y et al (2020) Recommendation of antimicrobial dosing optimization during continuous renal replacement therapy. Front Pharmacol 11:786. https://doi.org/10.3389/fphar.2020.00786

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Sutherland SM, Alexander SR (2012) Continuous renal replacement therapy in children. Pediatr Nephrol 27(11):2007–2016. https://doi.org/10.1007/s00467-011-2080-x

    Article  PubMed  Google Scholar 

  5. Sutherland SM, Zappitelli M, Alexander SR et al (2010) Fluid overload and mortality in children receiving continuous renal replacement therapy: the prospective pediatric continuous renal replacement therapy registry. Am J Kidney Dis 55(2):316–325. https://doi.org/10.1053/j.ajkd.2009.10.048

    Article  PubMed  Google Scholar 

  6. Cerdá J, Liu KD, Cruz DN et al (2015) Promoting kidney function recovery in patients with AKI requiring RRT. Clin J Am Soc Nephrol 10(10):1859–1867. https://doi.org/10.2215/cjn.01170215

    Article  PubMed  PubMed Central  Google Scholar 

  7. Clark EG, Bagshaw SM (2015) Unnecessary renal replacement therapy for acute kidney injury is harmful for renal recovery. Semin Dial Jan-Feb 28(1):6–11. https://doi.org/10.1111/sdi.12300

    Article  Google Scholar 

  8. Wei EY, Vuong KT, Lee E, Liu L, Ingulli E, Coufal NG (2023) Predictors of successful discontinuation of continuous kidney replacement therapy in a pediatric cohort. Pediatr Nephrol 38(7):2221–2231. https://doi.org/10.1007/s00467-022-05782-0

    Article  PubMed  Google Scholar 

  9. Menon S, Krallman KA, Arikan AA et al (2023) Worldwide exploration of renal replacement outcomes collaborative in kidney disease (WE-ROCK). Kidney Int Rep 8(8):1542–1552. https://doi.org/10.1016/j.ekir.2023.05.026

    Article  PubMed  PubMed Central  Google Scholar 

  10. Stenson EK, Alhamoud I, Alobaidi R, Bottari G, Fernandez SN, Fuhrman DY, Guzzi F, Marinari E, Mohamed T, Morgan CJ, Mottes TA, Neumayer TM, Ollberding N, Raggi V, Ricci Z, See E, Stanski NL, Zang H, Zangla EE, Gist KM, on behalf of WE-ROCK Investigators (2023) Effect of continuous renal replacement therapy liberation patterns on outcomes: a retrospective analysis of the worldwide exploration of renal replacement outcomes collaborative in kidney disease (WE-ROCK). In: 28th International Advances in Critical Care Nephrology AKI&CRRT Conference

  11. Stenson EK, Alhamoud I, Alobaidi R, Bottari G, Fernandez SN, Fuhrman DY, Guzzi F, Marinari E, Mohamed T, Morgan CJ, Mottes TA, Neumayer TM, Ollberding N, Raggi V, Ricci Z, See E, Stanski NL, Zang H, Zangla EE, Gist KM, on behalf of WE-ROCK Investigators (2023) Factors associated with major adverse kidney events at 90 days among children requiring continuous renal replacement therapy: a retrospective analysis of the worldwide exploration of renal replacement Outcomes Collaborative in Kidney Disease (WE-ROCK). In: 28th International Advances in Critical Care Nephrology AKI&CRRT Conference

  12. Pollack MM, Holubkov R, Funai T et al (2016) The pediatric risk of mortality score: update 2015. Pediatr Crit Care Med 17(1):2–9. https://doi.org/10.1097/pcc.0000000000000558

    Article  PubMed  PubMed Central  Google Scholar 

  13. Leteurtre S, Duhamel A, Salleron J, Grandbastien B, Lacroix J, Leclerc F (2013) PELOD-2: an update of the PEdiatric logistic organ dysfunction score. Crit Care Med 41(7):1761–1773. https://doi.org/10.1097/CCM.0b013e31828a2bbd

    Article  PubMed  Google Scholar 

  14. Alobaidi R, Morgan C, Basu RK, Stenson E, Featherstone R, Majumdar SR, Bagshaw SM (2018) Association between fluid balance and outcomes in critically ill children: a systematic review and meta-analysis. JAMA Pediatr 172(3):257–268. https://doi.org/10.1001/jamapediatrics.2017.4540

    Article  PubMed  PubMed Central  Google Scholar 

  15. Liu C, Peng Z, Dong Y et al (2021) Continuous renal replacement therapy liberation and outcomes of critically ill patients with acute kidney injury. Mayo Clin Proc 96(11):2757–2767. https://doi.org/10.1016/j.mayocp.2021.05.031

    Article  CAS  PubMed  Google Scholar 

  16. Jeon J, Kim DH, Baeg SI et al (2018) Association between diuretics and successful discontinuation of continuous renal replacement therapy in critically ill patients with acute kidney injury. Crit Care 22(1):255. https://doi.org/10.1186/s13054-018-2192-9

    Article  PubMed  PubMed Central  Google Scholar 

  17. Cho AY, Yoon HJ, Lee KY, Sun IO (2018) Clinical characteristics of sepsis-induced acute kidney injury in patients undergoing continuous renal replacement therapy. Renal Fail 40(1):403–409. https://doi.org/10.1080/0886022x.2018.1489288

    Article  CAS  Google Scholar 

  18. Goldstein SL, Somers MJ, Baum MA et al (2005) Pediatric patients with multi-organ dysfunction syndrome receiving continuous renal replacement therapy. Kidney Int 67(2):653–658. https://doi.org/10.1111/j.1523-1755.2005.67121.x

    Article  PubMed  Google Scholar 

  19. Symons JM, Chua AN, Somers MJ et al (2007) Demographic characteristics of pediatric continuous renal replacement therapy: a report of the prospective pediatric continuous renal replacement therapy registry. Clin J Am Soc Nephrol 2(4):732–738. https://doi.org/10.2215/cjn.03200906

    Article  PubMed  Google Scholar 

  20. Harrell FE (2015) Regression modeling strategies: with applications to linear models, logistic and ordinal regression, and survival analysis, 2nd edn. Springer Series in Statistics, Berlin

    Book  Google Scholar 

  21. Harrell FJ (2023) Regression modeling strategies. 2023. https://cran.r-project.org/web/packages/rms/index.html

  22. Wei EY, Vuong KT, Lee E, Liu L, Ingulli E, Coufal NG (2022) Predictors of successful discontinuation of continuous kidney replacement therapy in a pediatric cohort. Pediatr Nephrol. https://doi.org/10.1007/s00467-022-05782-0

    Article  PubMed  PubMed Central  Google Scholar 

  23. Liu C, Peng Z, Dong Y, Li Z, Andrijasevic NM, Albright RC Jr, Kashani KB (2021) Predicting successful continuous renal replacement therapy liberation in critically ill patients with acute kidney injury. J Crit Care 66:6–13. https://doi.org/10.1016/j.jcrc.2021.07.020

    Article  PubMed  Google Scholar 

  24. Hansrivijit P, Yarlagadda K, Puthenpura MM, Ghahramani N, Thongprayoon C, Vaitla P, Cheungpasitporn W (2020) A meta-analysis of clinical predictors for renal recovery and overall mortality in acute kidney injury requiring continuous renal replacement therapy. J Crit Care 60:13–22. https://doi.org/10.1016/j.jcrc.2020.07.012

    Article  PubMed  Google Scholar 

  25. Katulka RJ, Al Saadon A, Sebastianski M et al (2020) Determining the optimal time for liberation from renal replacement therapy in critically ill patients: a systematic review and meta-analysis (DOnE RRT). Crit Care 24(1):50. https://doi.org/10.1186/s13054-020-2751-8

    Article  PubMed  PubMed Central  Google Scholar 

  26. Murugan R, Bellomo R, Palevsky PM, Kellum JA (2021) Ultrafiltration in critically ill patients treated with kidney replacement therapy. Nat Rev Nephrol 17(4):262–276. https://doi.org/10.1038/s41581-020-00358-3

    Article  PubMed  Google Scholar 

  27. Murugan R, Kerti SJ, Chang CH et al (2019) Association of net ultrafiltration rate with mortality among critically ill adults with acute kidney injury receiving continuous venovenous hemodiafiltration: a secondary analysis of the randomized evaluation of normal vs augmented level (RENAL) of renal replacement therapy trial. JAMA Netw Open 2(6):e195418. https://doi.org/10.1001/jamanetworkopen.2019.5418

    Article  PubMed  PubMed Central  Google Scholar 

  28. Murugan R, Kerti SJ, Chang CH et al (2022) Association between net ultrafiltration rate and renal recovery among critically ill adults with acute kidney injury receiving continuous renal replacement therapy: an observational cohort study. Blood Purif 51(5):397–409. https://doi.org/10.1159/000517281

    Article  CAS  PubMed  Google Scholar 

  29. Riley AA, Watson M, Smith C, Guffey D, Minard CG, Currier H, Akcan Arikan A (2018) Pediatric continuous renal replacement therapy: have practice changes changed outcomes? A large single-center ten-year retrospective evaluation. BMC Nephrol 19(1):268. https://doi.org/10.1186/s12882-018-1068-1

    Article  PubMed  PubMed Central  Google Scholar 

  30. Pipili C, Vasileiadis I, Grapsa E et al (2016) Microcirculatory alterations during continuous renal replacement therapy in ICU: a novel view on the “dialysis trauma” concept. Microvasc Res 103:14–18. https://doi.org/10.1016/j.mvr.2015.09.004

    Article  PubMed  Google Scholar 

  31. Maynar Moliner J, Honore PM, Sánchez-Izquierdo Riera JA, Herrera Gutiérrez M, Spapen HD (2012) Handling continuous renal replacement therapy-related adverse effects in intensive care unit patients: the dialytrauma concept. Blood Purif 34(2):177–185. https://doi.org/10.1159/000342064

    Article  CAS  PubMed  Google Scholar 

  32. van der Sande FM, Dekker MJ, Leunissen KML, Kooman JP (2018) Novel insights into the pathogenesis and prevention of intradialytic hypotension. Blood Purif 45(1–3):230–235. https://doi.org/10.1159/000485160

    Article  PubMed  Google Scholar 

  33. Martin M, Bansal A, Perez L, Stenson EK, Kendrick J (2022) Use of relative blood volume monitoring to reduce intradialytic hypotension in hospitalized patients receiving dialysis. Kidney Int Rep 7(9):2105–2107. https://doi.org/10.1016/j.ekir.2022.06.018

    Article  PubMed  PubMed Central  Google Scholar 

  34. Wald R, Beaubien-Souligny W, Chanchlani R et al (2022) Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury. Intensive Care Med 48(10):1368–1381. https://doi.org/10.1007/s00134-022-06851-6

    Article  PubMed  Google Scholar 

  35. Wald R, Gaudry S, da Costa BR et al (2023) Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial. Intensive Care Med 49(11):1305–1316. https://doi.org/10.1007/s00134-023-07211-8

    Article  PubMed  Google Scholar 

  36. Hayes LW, Oster RA, Tofil NM, Tolwani AJ (2009) Outcomes of critically ill children requiring continuous renal replacement therapy. J Crit Care 24(3):394–400. https://doi.org/10.1016/j.jcrc.2008.12.017

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

T. Christine E. Alvarez MHI RN (Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA), Elizabeth Bixler BS (Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA), Erica Blender Brown MA, CRA (Medical University of South Carolina, Charleston, SC, USA), Cheryl L Brown BS (Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA), Ambra Burrell BA (Nationwide Children's Hospital, Columbus, OH, USA), Anwesh Dash BS (University of Tennessee Health Science Center College of Medicine, Memphis, TN, USA), Jennifer L Ehrlich RN MHA (University of Iowa Stead Family Children's Hospital, Carver College of Medicine, Iowa City, IA, USA), Simrandeep Farma HBSc (Hospital for Sick Children, Toronto, ON, Canada), Kim Gahring RN BSN, CCRN (Children's Hospital Colorado, Aurora, CO, USA), Barbara Gales RN (Mattel Children Hospital at UCLA, Los Angeles, CA, USA), Madison R Hilgenkamp (University of Nebraska Medical Center, Children's Hospital & Medical Center, Omaha, NE, USA), Sonal Jain MS (Seattle Children's Hospital, Seattle, WA, USA), Kate Kanwar BA MS (Nationwide Children's Hospital, Columbus, OH, USA), Jennifer Lusk BSN RN, CCRN (Children's Hospital Colorado, Aurora, CO, USA), Christopher J. Meyer BA AA (Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA), Katherine Plomaritas BSN RN (University of Michigan, C.S. Mott Children's Hospital, Ann Arbor, MI, USA), Joshua Porter BS (University of Tennessee Health Science Center College of Medicine, Memphis, TN, USA), Jessica Potts BSN RN (Children's of Alabama/University of Alabama at Birmingham, Birmingham, AL, USA), Alyssa Serratore BNurs, GDipNP(PIC), RN, MsC (Royal Children's Hospital, Melbourne, VIC, Australia), Elizabeth Schneider BS (University of Tennessee Health Science Center College of Medicine, Memphis, TN, USA), Vidushi Sinha BS (University of Tennessee Health Science Center College of Medicine, Memphis, TN, USA), PJ Strack RN,BSN,CCRN (Children's Mercy Hospital, Kansas City, MO, USA), Sue Taylor RN (King's College Hospital, London, England), Katherine Twombley MD (Medical University of South Carolina, Charleston, SC, USA), Brynna Van Wyk MSN, ARNP CPNP (University of Iowa Stead Family Children's Hospital, Carver College of Medicine, Iowa City, IA, USA), Samantha Wallace MS (Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN, USA), Janet Wang BS (University of Tennessee Health Science Center College of Medicine, Memphis, TN, USA), Megan Woods BS (University of Tennessee Health Science Center College of Medicine, Memphis, TN, USA), Marcia Zinger RN (Cohen Children's Medical Center, New Hyde Park, NY, USA), Alison Zong BS (University of Tennessee Health Science Center College of Medicine, Memphis, TN, USA)

WE ROCK collaborators and investigators. Emily Ahern CPNP, DNP (Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA), Ayse Akcan Arikan MD (Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA), Issa Alhamoud MD (University of Iowa Stead Family Children's Hospital, Carver College of Medicine, Iowa City, IA, USA), Rashid Alobaidi MD, MSc (Univeristy of Alberta, Edmonton, Canada), Pilar Anton-Martin MD, PhD (Le Bonheur Children's Hospital, Memphis, TN, USA), Shanthi S Balani MD (University of Minnesota, Minneapolis, MN, USA), Matthew Barhight MD, MS (Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA), Abby Basalely MD, MS (Cohen Children's Medical Center, Zucker School of Medicine, New Hyde Park, NY, USA), Amee M Bigelow MD, MS (Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA), Gabriella Bottari MD (Bambino Gesù Children Hospital, IRCCS, Rome, Italy), Andrea Cappoli MD (Bambino Gesù Children Hospital, IRCCS, Rome, Italy), Eileen A Ciccia MD (Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, USA), Michaela Collins BA (Cincinnati Children's Hospital Medical Center; University of Cincinnati College of Medicine, Cincinnati, OH, USA), Denise Colosimo MD (Meyer Children's Hospital, IRCCS, Florence, Italy), Gerard Cortina MD (Medical University of Innsbruck, Innsbruck, Austria), Mihaela A Damian MD, MPH (Stanford University School of Medicine, Palo Alto, CA, USA), Sara De la Mata Navazo MD (Gregorio Marañón University Hospital; School of Medicine, Madrid, Spain), Gabrielle DeAbreu MD (Cohen Children's Medical Center, Zucker School of Medicine, New Hyde Park, NY, USA), Akash Deep MD (King's College Hospital, London, England), Kathy L Ding BS (University of Colorado, School of Medicine, Aurora, CO, USA), Kristin J Dolan MD (Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA), Sarah N Fernandez Lafever MD, PhD (Gregorio Marañón University Hospital; School of Medicine, Madrid, Spain), Dana Y Fuhrman DO, MS (University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, PA, USA), Ben Gelbart MBBS (Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, Melbourne, Victoria, Australia), Katja M Gist , DO MSc (Cincinnati Children's Hospital Medical Center; University of Cincinnati College of Medicine, Cincinnati, OH, USA), Stephen M Gorga MD, MSc (University of Michigan Medical School, C.S. Mott Children's Hospital, Ann Arbor, MI, USA), Francesco Guzzi MD (Santo Stefano Hospital, Prato, Italy), Isabella Guzzo MD (Bambino Gesù Children Hospital, IRCCS, Rome, Italy), Taiki Haga MD (Osaka City General Hospital, Osaka, Japan), Elizabeth Harvey MD (Hospital for Sick Children, Toronto, Ontario, Canada), Denise C Hasson MD (NYU Langone Health, Hassenfeld Children’s Hospital, New York, NY, USA), Taylor Hill-Horowitz BS (Cohen Children's Medical Center, Zucker School of Medicine, New Hyde Park, NY, USA), Haleigh Inthavong BS, MS (Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA), Catherine Joseph MD (Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA), Ahmad Kaddourah MD, MS (Sidra Medicine and Weil Cornel Medicine, Qatar, Doha, Qatar), Aadil Kakajiwala MD, MSCI (Children's National Hospital, Washington, DC, USA), Aaron D Kessel MD, MS (Cohen Children's Medical Center, Zucker School of Medicine, New Hyde Park, NY, USA), Sarah Korn DO (Westchester Medical Center, Westchester, NY, USA), Kelli A Krallman BSN, MS (Cincinnati Children's Hospital Medical Center; University of Cincinnati College of Medicine, Cincinnati, OH, USA), David M Kwiatkowski MD Msc (Lucile Packard Children's Hospital, Palo Alto, CA, USA), Jasmine Lee MSc (Hospital for Sick Children, Toronto, Ontario, Canada), Laurance Lequier MD (Univeristy of Alberta, Edmonton, Canada), Tina Madani Kia BS (Univeristy of Alberta, Edmonton, Canada), Kenneth E Mah MD, MS (Stanford University School of Medicine, Palo Alto, CA, USA), Eleonora Marinari MD (Bambino Gesù Children Hospital, IRCCS, Rome, Italy), Susan D Martin MD (Golisano Children's Hospital at University of Rochester Medical Center, Rochester, NY, USA), Shina Menon MD (Seattle Children's Hospital, University of Washington, Seattle, WA, USA), Tahagod H Mohamed MD (Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA), Catherine Morgan MD MSc (Univeristy of Alberta, Edmonton, Canada), Theresa A Mottes APRN (Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA), Melissa A Muff-Luett MD (University of Nebraska Medical Center, Children's Hospital & Medical Center, Omaha, NE, USA), Siva Namachivayam MBBS (Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, Melbourne, Victoria, Australia), Tara M Neumayr MD (Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, USA), Jennifer Nhan Md, MS (Children's National Hospital, Washington, DC, USA), Abigail O'Rourke MD (Cohen Children's Medical Center, Zucker School of Medicine, New Hyde Park, NY, USA), Nicholas J Ollberding PhD (Cincinnati Children's Hospital Medical Center; University of Cincinnati College of Medicine, Cincinnati, OH, USA), Matthew G Pinto MD (Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, USA), Dua Qutob MD (Sidra Medicine and Weil Cornel Medicine, Qatar, Doha, Qatar), Valeria Raggi MD (Bambino Gesù Children Hospital, IRCCS, Rome, Italy), Stephanie Reynaud MD (Hopital Bicetre, APHP Université Paris-Saclay, Kremlin-Bicetre, Val de Marne, France), Zaccaria Ricci MD (Meyer Children's Hospital, IRCCS, Florence, Italy), Zachary A Rumlow DO (University of Iowa Stead Family Children's Hospital, Carver College of Medicine, Iowa City, IA, USA), María J Santiago Lozano MD, PhD (Gregorio Marañón University Hospital; School of Medicine, Madrid, Spain), Emily See MBBS (Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, Melbourne, Victoria, Australia), David T Selewski MD, MSCR (Medical University of South Carolina, Charleston, SC, USA), Carmela Serpe MSc, PhD (Bambino Gesù Children Hospital, IRCCS, Rome, Italy), Alyssa Serratore RN, MsC (Royal Children's Hospital, University of Melbourne, Murdoch Children's Research Institute, Melbourne, Victoria, Australia), Ananya Shah BS (University of Colorado, School of Medicine, Aurora, CO, USA), Weiwen V Shih MD (Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA, University of Colorado, School of Medicine, Aurora, CO, USA), H Stella Shin MD (Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA), Cara L Slagle MD (Cincinnati Children's Hospital Medical Center; University of Cincinnati College of Medicine, Cincinnati, OH, USA), Sonia Solomon DO (Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, USA), Danielle E Soranno MD (Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN, USA), Rachana Srivastava MD (Mattel Children's Hospital at UCLA, Los Angeles, Ca, USA), Natalja L Stanski MD (Cincinnati Children's Hospital Medical Center; University of Cincinnati College of Medicine, Cincinnati, OH, USA), Michelle C Starr MD, MPH (Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN, USA), Erin K Stenson MD (Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA, University of Colorado, School of Medicine, Aurora, CO, USA), Amy E Strong MD, MSCE (University of Iowa Stead Family Children's Hospital, Carver College of Medicine, Iowa City, IA, USA), Susan A Taylor MSc (King's College Hospital, London, England), Sameer V Thadani MD (Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA), Amanda M Uber DO (University of Nebraska Medical Center, Children's Hospital & Medical Center, Omaha, NE, USA), Brynna Van Wyk ARNP, MSN (University of Iowa Stead Family Children's Hospital, Carver College of Medicine, Iowa City, IA, USA), Tennille N Webb MD, MSPH (Children's of Alabama/University of Alabama at Birmingham, Birmingham, AL, USA), Huaiyu Zang PhD (Cincinnati Children's Hospital Medical Center; University of Cincinnati College of Medicine, Cincinnati, OH, USA), Emily E Zangla DO (University of Minnesota, Minneapolis, MN, USA), Michael Zappitelli MD, MSc (Hospital for Sick Children, Toronto, Ontario, Canada)

Funding

REDCap at Cincinnati Children’s Hospital Medical Center is funded and supported by the Center for Clinical and Translational Science and Training grant support (UL1TR001425). The funding sources for this study had no role in the design, conduct, collection, management, analysis, and interpretation of the data, nor the preparation, review, or decision to submit the manuscript for publication.

Author information

Authors and Affiliations

  1. Children’s Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA

    Erin K. Stenson

  2. Carver College of Medicine, University of Iowa Stead Family Children’s Hospital, Iowa City, IA, USA

    Issa Alhamoud

  3. University of Alberta, Edmonton, Canada

    Rashid Alobaidi & Catherine Morgan

  4. Bambino Gesù, Children’s Hospital, IRCCS, Rome, Italy

    Gabriella Bottari, Eleonora Marinari & Valeria Raggi

  5. School of Medicine, Gregorio Marañón University Hospital, Madrid, Spain

    Sarah Fernandez

  6. University of Pittsburgh Medical Center Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA

    Dana Y. Fuhrman

  7. Santo Stefano Hospital, Prato, Italy

    Francesco Guzzi

  8. Osaka City General Hospital, Osaka, Japan

    Taiki Haga

  9. Nationwide Children’s Hospital, The Kidney and Urinary Tract Center, The Ohio State University College of Medicine, Columbus, OH, USA

    Tahagod Mohamed

  10. Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA

    Theresa Mottes

  11. St. Louis Children’s Hospital, Washington University School of Medicine, St. Louis, MO, USA

    Tara Neumayr & Katja M. Gist

  12. Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Nicholas J. Ollberding, Natalja L. Stanski & Huaiyu Zang

  13. Department of Pediatrics, Pediatric Intensive Care Unit, Meyer Children’s Hospital, IRCCS, Florence, Italy

    Zaccaria Ricci

  14. Royal Children’s Hospital, Murdoch Children’s Research Institute, University of Melbourne, Melbourne, VIC, Australia

    Emily See

  15. University of Minnesota, Minneapolis, MN, USA

    Emily Zangla

  16. Sidra Medicine and Weill Cornell Medicine, Doha, Qatar

    Ahmad Kaddourah

Authors
  1. Erin K. Stenson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Issa Alhamoud
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rashid Alobaidi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gabriella Bottari
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sarah Fernandez
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Dana Y. Fuhrman
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Francesco Guzzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Taiki Haga
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Ahmad Kaddourah
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Eleonora Marinari
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Tahagod Mohamed
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Catherine Morgan
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Theresa Mottes
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Tara Neumayr
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Nicholas J. Ollberding
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Valeria Raggi
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Zaccaria Ricci
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Emily See
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Natalja L. Stanski
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. Huaiyu Zang
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. Emily Zangla
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. Katja M. Gist
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

the WE-ROCK Investigators

  • Andrea Cappoli
  • , Eileen A Ciccia
  • , Michaela Collins
  • , Denise Colosimo
  • , Gerard Cortina
  • , Mihaela A Damian
  • , Sara De la Mata Navazo
  • , Gabrielle DeAbreu
  • , Akash Deep
  • , Kathy L Ding
  • , Kristin J Dolan
  • , Sarah N Lafever Fernandez
  • , Dana Y Fuhrman
  • , Ben Gelbart
  • , Katja M Gist
  • , Stephen M Gorga
  • , Francesco Guzzi
  • , Isabella Guzzo
  • , Taiki Haga
  • , Elizabeth Harvey
  • , Denise C Hasson
  • , Taylor Hill-Horowitz
  • , Haleigh Inthavong
  • , Catherine Joseph
  • , Ahmad Kaddourah
  • , Aadil Kakajiwala
  • , Aaron D Kessel
  • , Sarah Korn
  • , Kelli A Krallman
  • , David M Kwiatkowski
  • , Jasmine Lee
  • , Laurance Lequier
  • , Tina Madani Kia
  • , Kenneth E Mah
  • , Eleonora Marinari
  • , Susan D Martin
  • , Shina Menon
  • , Tahagod H Mohamed
  • , Catherine Morgan
  • , Theresa A Mottes
  • , Melissa A Muff-Luett
  • , Siva Namachivayam
  • , Tara M Neumayr
  • , Jennifer Nhan
  • , Abigail O’Rourke
  • , Nicholas J Ollberding
  • , Matthew G Pinto
  • , Dua Qutob
  • , Valeria Raggi
  • , Stephanie Reynaud
  • , Zaccaria Ricci
  • , Zachary A Rumlow
  • , María J Lozano Santiago
  • , Emily See
  • , David T Selewski
  • , Carmela Serpe
  • , Alyssa Serratore
  • , Ananya Shah
  • , Weiwen V Shih
  • , H Shin Stella
  • , Cara L Slagle
  • , Sonia Solomon
  • , Danielle E Soranno
  • , Rachana Srivastava
  • , Natalja L Stanski
  • , Michelle C Starr
  • , Erin K Stenson
  • , Amy E Strong
  • , Susan A Taylor
  • , Sameer V Thadani
  • , Amanda M Uber
  • , Brynna Wyk
  • , Tennille N Webb
  • , Huaiyu Zang
  • , Emily E Zangla
  •  & Michael Zappitelli

Corresponding author

Correspondence to Erin K. Stenson.

Ethics declarations

Conflicts of interest

All authors declare no real or perceived conflicts of interest that could affect the study design, collection, analysis and interpretation of data, writing of the report, or the decision to submit for publication. For full disclosure, we provide here an additional list of other author’s commitments and funding sources that are not directly related to this study: KG is a consultant for Bioporto Diagnostics and Potrero Medical. No other disclosures were reported.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

The members of WE ROCK Collaborative are listed in the Acknowledgements section.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 34 KB)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Stenson, E.K., Alhamoud, I., Alobaidi, R. et al. Factors associated with successful liberation from continuous renal replacement therapy in children and young adults: analysis of the worldwide exploration of renal replacement outcomes collaborative in Kidney Disease Registry. Intensive Care Med (2024). https://doi.org/10.1007/s00134-024-07336-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s00134-024-07336-4

Keywords

Search

Navigation