Skip to main content
Log in

Long-term outcomes of intensive care unit delirium

  • What's New in Intensive Care
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Data availability

This is a review. We do not use any individual data on it.

References

  1. Wilson JE, Mart MF, Cunningham C, Shehabi Y, Girard TD, MacLullich AMJ, Slooter AJC, Ely EW (2020) Delirium. Nat Rev Dis Primers 6:90

    Article  PubMed  PubMed Central  Google Scholar 

  2. Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH (2009) Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med 180:1092–1097

    Article  PubMed  PubMed Central  Google Scholar 

  3. Hughes CG, Hayhurst CJ, Pandharipande PP, Shotwell MS, Feng X, Wilson JE, Brummel NE, Girard TD, Jackson JC, Ely EW, Patel MB (2021) Association of delirium during critical illness with mortality: multicenter prospective cohort study. Anesth Analg 133:1152–1161

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Fiest KM, Soo A, Hee Lee C, Niven DJ, Ely EW, Doig CJ, Stelfox HT (2021) Long-term outcomes in ICU patients with delirium: a population-based cohort study. Am J Respir Crit Care Med 204:412–420

    Article  PubMed  PubMed Central  Google Scholar 

  5. Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW (2013) Long-term cognitive impairment after critical illness. N Engl J Med 369:1306–1316

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Fong TG, Inouye SK (2022) The inter-relationship between delirium and dementia: the importance of delirium prevention. Nat Rev Neurol 18:579–596

    Article  PubMed  PubMed Central  Google Scholar 

  7. Gunther ML, Morandi A, Krauskopf E, Pandharipande P, Girard TD, Jackson JC, Thompson J, Shintani AK, Geevarghese S, Miller RR 3rd, Canonico A, Merkle K, Cannistraci CJ, Rogers BP, Gatenby JC, Heckers S, Gore JC, Hopkins RO, Ely EW (2012) The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: the VISIONS cohort magnetic resonance imaging study*. Crit Care Med 40:2022–2032

    Article  PubMed  PubMed Central  Google Scholar 

  8. Morandi A, Rogers BP, Gunther ML, Merkle K, Pandharipande P, Girard TD, Jackson JC, Thompson J, Shintani AK, Geevarghese S, Miller RR 3rd, Canonico A, Cannistraci CJ, Gore JC, Ely EW, Hopkins RO (2012) The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study*. Crit Care Med 40:2182–2189

    Article  PubMed  PubMed Central  Google Scholar 

  9. Hayhurst CJ, Marra A, Han JH, Patel MB, Brummel NE, Thompson JL, Jackson JC, Chandrasekhar R, Ely EW, Pandharipande PP, Hughes CG (2020) Association of hypoactive and hyperactive delirium with cognitive function after critical illness. Crit Care Med 48:e480–e488

    Article  PubMed  PubMed Central  Google Scholar 

  10. Girard TD, Thompson JL, Pandharipande PP, Brummel NE, Jackson JC, Patel MB, Hughes CG, Chandrasekhar R, Pun BT, Boehm LM, Elstad MR, Goodman RB, Bernard GR, Dittus RS, Ely EW (2018) Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study. Lancet Respir Med 6:213–222

    Article  PubMed  PubMed Central  Google Scholar 

  11. Rengel KF, Hayhurst CJ, Jackson JC, Boncyk CS, Patel MB, Brummel NE, Shi Y, Shotwell MS, Ely EW, Pandharipande PP, Hughes CG (2021) Motoric subtypes of delirium and long-term functional and mental health outcomes in adults after critical illness. Crit Care Med 49:e521–e532

    Article  PubMed  PubMed Central  Google Scholar 

  12. Altman MT, Knauert MP, Murphy TE, Ahasic AM, Chauhan Z, Pisani MA (2018) Association of intensive care unit delirium with sleep disturbance and functional disability after critical illness: an observational cohort study. Ann Intensive Care 8:63

    Article  PubMed  PubMed Central  Google Scholar 

  13. Burry LD, Cheng W, Williamson DR, Adhikari NK, Egerod I, Kanji S, Martin CM, Hutton B, Rose L (2021) Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Med 47:943–960

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Chen TJ, Traynor V, Wang AY, Shih CY, Tu MC, Chuang CH, Chiu HY, Chang HR (2022) Comparative effectiveness of non-pharmacological interventions for preventing delirium in critically ill adults: a systematic review and network meta-analysis. Int J Nurs Stud 131:104239

    Article  PubMed  Google Scholar 

  15. Patel BK, Wolfe KS, Patel SB, Dugan KC, Esbrook CL, Pawlik AJ, Stulberg M, Kemple C, Teele M, Zeleny E, Hedeker D, Pohlman AS, Arora VM, Hall JB, Kress JP (2023) Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial. Lancet Respir Med. https://doi.org/10.1016/S2213-2600(22)00489-1

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Antonio Paulo Nassar.

Ethics declarations

Conflicts of interest

APNJ has received personal financial support from the Brazilian National Council for Scientific Development (CNPq). EWE has ongoing NIH and VA funding and has received honoraria from Pfizer for CME activities. He has no stocks or consultancies with any pharma or other industry groups. KMF has no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nassar, A.P., Ely, E.W. & Fiest, K.M. Long-term outcomes of intensive care unit delirium. Intensive Care Med 49, 677–680 (2023). https://doi.org/10.1007/s00134-023-07029-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-023-07029-4

Navigation