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References
Mohr L, Faine B (2023) Etomidate for endotracheal intubation in sepsis. Intensive Care Med. https://doi.org/10.1007/s00134-022-06962-0
Matchett G, Gasanova I, Riccio CA, Nasir D, Sunna MC, Bravenec BJ, Azizad O, Farrell B, Minhajuddin A, Stewart JW, Liang LW, Moon TS, Fox PE, Ebeling CG, Smith MN, Trousdale D, Ogunnaike BO, EvK Clinical Trial Collaborators (2022) Etomidate versus ketamine for emergency endotracheal intubation: a randomized clinical trial. Intensive Care Med 48(1):78–91
Jabre P, Combes X, Lapostolle F, Dhaouadi M, Ricard-Hibon A, Vivien B, Bertrand L, Beltramini A, Gamand P, Albizzati S, Perdrizet D, Lebail G, Chollet-Xemard C, Maxime V, Brun-Buisson C, Lefrant JY, Bollaert PE, Megarbane B, Ricard JD, Anguel N, Vicaut E, Adnet F, KETASED Collaborative Study Group (2009) Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet 374(9686):293–300
Tekwani KL, Watts HF, Sweis RT, Rzechula KH, Kulstad EB (2010) A comparison of the effects of etomidate and midazolam on hospital length of stay in patients with suspected sepsis: a prospective, randomized study. Ann Emerg Med 56(5):481–489
Cuthbertson BH, Sprung CL, Annane D, Chevret S, Garfield M, Goodman S, Laterre PF, Vincent JL, Freivogel K, Reinhart K, Singer M, Payen D, Weiss YG (2009) The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med 35(11):1868–1876
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Internally funded (UT-Southwestern Dept. of Anesthesiology & Pain Management, Dallas, Texas).
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TMS declares research grants from Merck and MDoloris (both unrelated to this work). All the other Authors have no conflicts to disclose.
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The study PI (GM) is responsible for the veracity of all study data and all aspects of this manuscript.
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This trial referenced in this letter (NCT02643381, UTSW IRB STU022015-023) received contingent Institutional Review Board (IRB) approval on 28 October 2015, and full approval on 30 November 2015. Continuing Reviews were completed and approved on 19 August 2016, 3 August 2017, 26 July 2018, 7 August 2019, and 7 August 2020.
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Matchett, G., Moon, T.S., Stewart, J.W. et al. Etomidate for endotracheal intubation in sepsis. Author’s reply. Intensive Care Med 49, 370–371 (2023). https://doi.org/10.1007/s00134-023-06987-z
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DOI: https://doi.org/10.1007/s00134-023-06987-z