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Mental health-related quality of life is related to delirium in intensive care patients

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Abstract

Purpose

Delirium during intensive care unit (ICU) stay may be related to premorbid mental illness. In addition, delirium during ICU stay may also negatively affect long-term health-related quality of life. The aim of our study was to investigate if delirium in the ICU is related to premorbid mental quality of life and affects long-term mental quality of life after ICU stay.

Methods

We performed a prospective cohort study in 1021 patients admitted for longer than 48 h in a medical-surgical ICU. We evaluated mental and physical quality of life using the Short-form-12 before ICU admission, at hospital discharge, and 3, 6 and 12 months after hospital discharge. Mixed model and logistic regression models were used to analyze the data.

Results

Patients who experienced a delirium during ICU stay reported a worse pre-admission mental quality of life than those without delirium (p < 0.001). Furthermore, patients who suffered from delirium during their ICU stay exhibited a significant decrease in mental quality of life over time relative to patients without delirium (p = 0.035).

Conclusion

In this large follow-up study, we demonstrated that ICU survivors who experienced a delirium during ICU stay reported a significantly worse pre-admission mental health-related quality of life and a significant decrease in mental health-related quality of life in the year after hospital discharge compared with patients without delirium.

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Availability of data and materials

All data generated or analyzed during this study are included in this published article and its supplementary information files.

Abbreviations

ICU:

Intensive care unit

IQR:

Interquartile range (P25–P75)

HRQOL:

Health-related quality of life

SF-12:

Short-form 12

MCS:

Mental component score

PCS:

Physical component score

CAM-ICU:

Confusion assessment method

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Author information

Authors and Affiliations

  1. Department of Intensive Care, Gelre Hospitals, Albert Schweitzerlaan 31, 7334 DZ, Apeldoorn, The Netherlands

    José G. M. Hofhuis & Peter E. Spronk

  2. Expertise Center for Intensive Care Rehabilitation Apeldoorn (ExpIRA), Albert Schweitzerlaan 31, 7334 DZ, Apeldoorn, The Netherlands

    José G. M. Hofhuis & Peter E. Spronk

  3. Department of Epidemiology, Gelre Hospitals, Albert Schweitzerlaan 31, 7334 DZ, Apeldoorn, The Netherlands

    Tjard Schermer

  4. Department of Intensive Care, University Medical Center Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

    Peter E. Spronk

  5. Radboud Institute for Health Sciences, Radboud University Medical Center, Geert Grooteplein 21, 6525 EZ, Nijmegen, The Netherlands

    Tjard Schermer

Authors
  1. José G. M. Hofhuis
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  3. Peter E. Spronk
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Contributions

JH carried out the study, participated to the analysis and in the interpretation of the data, and drafted the manuscript. TS performed the analyses, interpretation of the data, and helped to draft the manuscript. PS conceived of the study, participated in its design, the interpretation of the data, and approved the final manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to José G. M. Hofhuis.

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Conflicts of interest

The author (s) declare that they have no competing interest.

Ethical approval

The hospital’s institutional research review board of Gelre Hospital Apeldoorn, The Netherlands approved the study.

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Hofhuis, J.G.M., Schermer, T. & Spronk, P.E. Mental health-related quality of life is related to delirium in intensive care patients. Intensive Care Med 48, 1197–1205 (2022). https://doi.org/10.1007/s00134-022-06841-8

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  • DOI: https://doi.org/10.1007/s00134-022-06841-8

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