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Prediction model for intracranial hypertension demonstrates robust performance during external validation on the CENTER-TBI dataset

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References

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Acknowledgement

Data used in preparation of this manuscript were obtained in the context of the CENTER-TBI Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI). CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators: Audny Anke, Department of Physical Medicine and Rehabilitation, University Hospital Northern Norway; Ronny Beer, Department of Neurology, Neurological Intensive Care Unit, Medical University of Innsbruck, Innsbruck, Austria; Bo-Michael Bellander, Department of Neurosurgery and Anesthesia and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden; Erta Beqiri, NeuroIntensive Care, Niguarda Hospital, Milan, Italy; Andras Buki, Department of Neurosurgery, Medical School, University of Pe´cs, Hungary and Neurotrauma Research Group, Ja´nos Szenta´gothai Research Centre, University of Pe´cs, Hungary; Manuel Cabeleira, Brain Physics Lab, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom; Marco Carbonara, Neuro ICU, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Milan, Italy ; Arturo Chieregato, NeuroIntensive Care, Niguarda Hospital, Milan, Italy; Giuseppe Citerio, NeuroIntensive Care Unit, Department of Anesthesia and Intensive Care, ASST di Monza, Monza, Italy/ School of Medicine and Surgery, Universita` Milano Bicocca, Milano, Italy; Hans Clusmann, Department of Neurosurgery, Medical Faculty RWTH Aachen University, Aachen, Germany; Endre Czeiter, Department of Neurosurgery, University of Pecs and MTA-PTE Clinical Neuroscience MR Research Group and Janos Szentagothai Research Centre, University of Pecs, Hungarian Brain Research Program (Grant No. KTIA 13 NAP-A-II/8), Pecs, Hungary; Marek Czosnyka, Brain Physics Lab, Division of Neurosurgery, Dept of Clinical Neurosciences, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK; Bart Depreitere, Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium; Ari Ercole, Division of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom; Shirin Frisvold, Department of Anesthesiology and Intensive Care, University Hospital Northern Norway, Tromso, Norway; Raimund Helbok, Department of Neurology, Neurological Intensive Care Unit, Medical University of Innsbruck, Innsbruck, Austria; Stefan Jankowski, Neurointensive Care, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom; Danile Kondziella, Departments of Neurology, Clinical Neurophysiology and Neuroanesthesiology, Region Hovedstaden Rigshospitalet, Copenhagen, Denmark; Lars-Owe Koskinen, Department of Clinical Neuroscience, Neurosurgery, Umea° University, Umea°, Sweden; Ana Kowark, Department of Anaesthesiology, University Hospital of Aachen, Aachen, Germany; David K. Menon, Division of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom; Geert Meyfroidt, Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium; Kirsten Moeller, Department Neuroanesthesiology, Region Hovedstaden Rigshospitalet, Copenhagen, Denmark; David Nelson, Department of Neurosurgery and Anesthesia and intensive care medicine, Karolinska University Hospital, Stockholm, Sweden; Anna Piippo-Karjalainen, Helsinki University Central Hospital, Helsinki, Finland; Andreea Radoi, Department of Neurosurgery, Vall d’Hebron University Hospital, Barcelona, Spain; Arminas Ragauskas, Department of Neurosurgery, Kaunas University of Technology and Vilnius University, Vilnius, Lithuania; Rahul Raj, Helsinki University Central Hospital, Helsinki, Finland; Jonathan Rhodes, Department of Anaesthesia, Critical Care and Pain Medicine NHS Lothian and University of Edinburg, Edinburgh, United Kingdom; Saulius Rocka, Department of Neurosurgery, Kaunas University of Technology and Vilnius University, Vilnius, Lithuania; Rolf Rossaint, Department of Anaesthesiology, University Hospital of Aachen, Aachen, Germany; Juan Sahuquillo, Department of Neurosurgery, Vall d’Hebron University Hospital, Barcelona, Spain; Oliver Sakowitz, Klinik fu¨ r Neurochirurgie, Klinikum Ludwigsburg, Ludwigsburg, Germany/ Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany; Peter Smielewski, Brain Physics Lab, Division of Neurosurgery, Dept of Clinical Neurosciences, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom; Nino Stocchetti, Department of Pathophysiology and Transplantation, Milan University, and Neuroscience ICU, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Milano, Italy; Nina Sundstro¨m, Department of Radiation Sciences, Biomedical Engineering, Umea University, Umea, Sweden; Riikka Takala, Perioperative Services, Intensive Care Medicine, and Pain Management , Turku University Central Hospital and University of Turku, Turku, Finland; Tomas Tamosuitis, Neuro-intensive Care Unit, Kaunas University of Health Sciences, Kaunas, Lithuania; Olli Tenovuo, Rehabilitation and Brain Trauma, Turku University Central Hospital and University of Turku, Turku, Finland; Peter Vajkoczy, Neurologie, Neurochirurgie und Psychiatrie, Charite´—Universita¨tsmedizin Berlin, Berlin, Germany; Alessia Vargiolu, NeuroIntensive Care Unit, Department of Anesthesia and Intensive Care, ASST di Monza, Monza, Italy; Rimantas Vilcinis, Department of Neurosurgery, Kaunas University of Health Sciences, Kaunas, Lithuania; Stefan Wolf, Department of Neurosurgery, Charite´—Universita¨tsmedizin Berlin, corporate member of Freie Universita¨t Berlin, Humboldt-Universita¨t zu Berlin, and Berlin Institute of Health, Berlin, Germany; Alexander Younsi, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany; Frederick A. Zeiler, Division of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom/ Section of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Funding

GC receives funding from the Research Foundation, Flanders (FWO) as a PhD fellow (fellowship number: 1S28120 N). GM is supported by the Research Foundation, Flanders (FWO) as senior clinical investigator (1843118 N). GM and FG receive project funding from the KU Leuven [C2 project (C24/17/072): A Neuromonitor for the twenty-first century)]. Data used in preparation of this manuscript were obtained from the CENTER-TBI Consortium. The collection of the CENTER-TBI Database was supported by the FP7 program of the European Union (EC grant 602150).

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Correspondence to Geert Meyfroidt.

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GC, GM, and FG declare not to have any conflicts of interest. BD reports grants from Medtronic, grants from Johnson & Johnson, outside the submitted work.

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The CENTER-TBI High-Resolution ICU (HR-ICU) Sub-Study Participants and Investigators are listed in the Acknowledgement section.

Giorgia Carra and Fabian Güiza contributed equally to this work.

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Carra, G., Güiza, F., Depreitere, B. et al. Prediction model for intracranial hypertension demonstrates robust performance during external validation on the CENTER-TBI dataset. Intensive Care Med 47, 124–126 (2021). https://doi.org/10.1007/s00134-020-06247-4

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