We thank Rech TH and co-workers  for their interest in our study . The incidence of pulmonary embolism (PE) in patients with SARS-CoV-2 may be influenced by the number of CT pulmonary angiography (CTPA) performed when PE is suspected.
In our study, CTPA was performed in a population in which we were looking for a cause to clinical deterioration, which might be due to PE, but also to mechanical ventilation-acquired pneumonia. We therefore did not necessarily select a population with a strong suspicion of PE. We did not have a systematic standardized assessment of thromboembolic events as well. Imaging was thus performed based on the evolution of clinical or laboratory parameters. Respiratory (PaO2/FiO2) or hemodynamic deterioration, or evidence of dilated right ventricle—even without acute cor pulmonale—was explored by CTPA. A rapid elevation of D-dimer despite anticoagulation, reflecting increased thrombin generation, i.e., clot formation, and fibrinolysis, was investigated. D-dimer level did not differ at baseline between patients with/without pulmonary embolism, but increased with thrombotic events during ICU stay, with D-dimers > 5 mg/L in 92% of the patients. A sudden increase in D-dimer level along with clinical deterioration was an additional argument to explore patients by CTPA.
The number of CTPA performed in our study to detect PE is indeed rather high. However, bed chest X-ray was time-consuming and of poor interest in COVID-19 wards. Lung ultrasonography was thus routinely used to detect condensation or pleural effusion. We decided to perform CT-scan to (re)explore patients when ultrasonography alone could not explain blood gas deterioration. In the historical cohort of non-COVID-19 ARDS, 168 CT-scans were performed in 134 patients during their ICU stay, among which 65 were CTPA. The incidence of PE found was of 4.6% in the non-COVID ARDS cohort compared to 25% in the present COVID-19 cohort. We had the same clinical/biological arguments to ask for a CTPA in the historical cohort. Yet, only 28% of the patients required CTPA, which may have led to a potential bias of an increased detection of PE in COVID-19 patients. Finally, even if we exclude subsegmentary PE, the difference between COVID-19 and non-COVID ARDS remains statistically significant (3/233 patients, 1.3%, versus 22/150 patients, 14.7%, p < 0.001).
Our study reports a high rate of PE, in line with other studies published concomitantly. In 184 ICU patients with proven COVID-19 pneumonia, Klok et al.  showed that the cumulative incidence of the composite outcome including venous thromboembolism and arterial thrombotic complications was 31% (95%CI 20–41%) and that CTPA-diagnosed PE was the most frequent thrombotic complication (n = 25, 81%). Poissy et al. reported that 22/107 COVID-19 patients (20.6%) admitted in ICU were diagnosed with PE, with an absolute increase risk of 14.4% (95%CI 6.1 to 22.8%) compared to patients hospitalized in the same ICU during the same time interval in 2019 (20.6% vs 6.1%; absolute increase risk of 14.4%, 95%CI 6.1 to 22.8%) . In a smaller cohort, Llitjos et al.  reported 6 PE in 26 patients (23%) (4 CTPA and 2 transesophageal echocardiography diagnosis). These studies are, however, difficult to compare, because the incidence of PE reported may depend on the number of CTPA performed on the global cohort.
Although PE is a major thromboembolic complication in ICU, no study has systematically assessed the incidence or prevalence of this complication in ICU COVID-19 patients. Systematic CTPA screening of all patients irrespective of symptoms is the only way to assess the incidence of PE. Despite a number of limitations, our study has the strengths of being multicenter and prospective, and reporting for the first time a large number of patients. Our results are of pressing importance to better understand peculiarities of the many patients currently treated during the ongoing COVID-19 crisis worldwide. Potentially practice changes may be envisaged in terms of anticoagulation, coagulopathy profile and systematic assessment of venous thromboembolism.
Rech TH et al (2020) Incidence of pulmonary embolism in patients with COVID-19. Intensive Care Med (In Press)
Helms J, Tacquard C, Severac F, Leonard-Lorant I, Ohana M, Delabranche X, Merdji H, Clere-Jehl R, Schenck M, Fagot Gandet F, Fafi-Kremer S, Castelain V, Schneider F, Grunebaum L, Anglés-Cano E, Sattler L, Mertes PM, Meziani F (2020) High risk of thrombosis in patients in severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med. https://doi.org/10.1007/s00134-020-06062-x
Klok FA, Kruip M, van der Meer NJM, Arbous MS, Gommers D, Kant KM, Kaptein FHJ, van Paassen J, Stals MAM, Huisman MV, Endeman H (2020) Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. https://doi.org/10.1016/j.thromres.2020.04.013
Poissy J, Goutay J, Caplan M, Parmentier E, Duburcq T, Lassalle F, Jeanpierre E, Rauch A, Labreuche J, Susen S, Lille ICUHC-g, (2020) Pulmonary embolism in COVID-19 patients: awareness of an increased prevalence. Circulation. https://doi.org/10.1161/CIRCULATIONAHA.120.047430
Llitjos JF, Leclerc M, Chochois C, Monsallier JM, Ramakers M, Auvray M, Merouani K (2020) High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients. J Thromb Haemost. https://doi.org/10.1111/jth.14869
Conflict of interest
The authors declare that they have no conflict of interest.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Helms, J., Severac, F., Merdji, H. et al. Prothrombotic phenotype in COVID-19 severe patients. Intensive Care Med 46, 1502–1503 (2020). https://doi.org/10.1007/s00134-020-06082-7