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Understanding necrotizing soft tissue infections in the intensive care unit

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Fig. 1

Abbreviations

ATB:

Antibiotics

GAS:

Group A streptococcus

ICU:

Intensive care unit

ID:

Infectious diseases

MRI:

Magnetic resonance imaging

NSTI:

Necrotizing soft-tissue infection

References

  1. Peetermans M, de Prost N, Eckmann C et al (2020) Necrotizing skin and soft-tissue infections in the intensive care unit. Clin Microbiol Infect 26:8–17

    Article  CAS  Google Scholar 

  2. Sartelli M, Guirao X, Hardcastle TC et al (2018) 2018 WSES/SIS-E consensus conference: recommendations for the management of skin and soft-tissue infections. World J Emerg Surg 13:58

    Article  Google Scholar 

  3. Henri Mondor Hospital Necrotizing Fasciitis Group, de Prost N, Sbidian E et al (2015) Management of necrotizing soft tissue infections in the intensive care unit: results of an international survey. Intensive Care Med 41:1506–1508

    Article  Google Scholar 

  4. INFECT study group, Madsen MB, Skrede S et al (2019) Patient’s characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study. Intensive Care Med 45:1241–1251

    Article  Google Scholar 

  5. Stevens DL, Bisno AL, Chambers HF et al (2014) Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 Update by the infectious diseases society of America. Clin Infect Dis 59:e10–e52

    Article  Google Scholar 

  6. Fernando SM, Tran A, Cheng W et al (2019) Necrotizing soft tissue infection: diagnostic accuracy of physical examination, imaging, and LRINEC Score. Ann Surg 269:58–65

    Article  Google Scholar 

  7. Howell EC, Keeley JA, Kaji AH et al (2019) Chance to cut: defining a negative exploration rate in patients with suspected necrotizing soft tissue infection. Trauma Surg Acute Care Open 4:e000264

    Article  Google Scholar 

  8. Hietbrink F, Bode LG, Riddez L et al (2016) Triple diagnostics for early detection of ambivalent necrotizing fasciitis. World J Emerg Surg 11(11):51

    Article  Google Scholar 

  9. Gatti M, Gasparini LE, Laratta M et al (2019) Intensive multidisciplinary management in critical care patients affected by severe necrotizing soft tissue infections: a cooperative method to improve the efficacy of treatment. Eur J Clin Microbiol Infect Dis 38(6):1153–1162

    Article  Google Scholar 

  10. Urbina T, Hua C, Sbidian E et al (2019) Impact of a multidisciplinary care bundle for necrotizing skin and soft tissue infections: a retrospective cohort study. Ann Intensive Care 9(1):123

    Article  Google Scholar 

  11. Boyer A, Vargas F, Coste F et al (2009) Influence of surgical treatment timing on mortality from necrotizing soft tissue infections requiring intensive care management. Intensive Care Med 35:847–853

    Article  Google Scholar 

  12. Audureau E, Hua C, de Prost N et al (2017) Mortality of necrotizing fasciitis: relative influence of individual and hospital-level factors, a nationwide multilevel study, France, 2007–12. Br J Dermatol 177:1575–1582

    Article  CAS  Google Scholar 

  13. Holena DN, Mills AM, Carr BG et al (2011) Transfer status: a risk factor for mortality in patients with necrotizing fasciitis. Surgery 150:363–370

    Article  Google Scholar 

  14. Madsen MB, Hjortrup PB, Hansen MB et al (2017) Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial. Intensive Care Med 43:1585–1593

    Article  CAS  Google Scholar 

  15. INFECT study group, Thänert R, Itzek A, et al (2019) Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections. Nat Commun 10:3846

    Article  Google Scholar 

  16. Phase III Efficacy and Safety Study of AB103 in the treatment of patients with necrotizing soft tissue infections. https://clinicaltrials.gov/ct2/show/NCT02469857

  17. Rodriguez C, Jary A, Hua C, et al (2019) Pathogen identification by shotgun metagenomics of patients with necrotizing soft‐tissue infections. Br J Dermatol bjd.18611 Oct 14

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Correspondence to Nicolas de Prost.

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Urbina, T., Madsen, M.B. & de Prost, N. Understanding necrotizing soft tissue infections in the intensive care unit. Intensive Care Med 46, 1739–1742 (2020). https://doi.org/10.1007/s00134-020-06071-w

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  • DOI: https://doi.org/10.1007/s00134-020-06071-w

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