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Revisiting oxygen dissociation curves and bedside measured arterial saturation in critically ill children

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Fig. 1



Oxygen dissociation curve

SpO2 :

Peripheral oxygen saturation derived from the pulse oximeter

SO2 :

Blood hemoglobin oxygen saturation

pO2 :

Partial pressure of oxygen in the blood

pCO2 :

Partial pressure of carbon dioxide in the blood


  1. 1.

    Hill AV (1913) The combinations of haemoglobin with oxygen and with carbon monoxide. I. Biochem J 7:471–480

    CAS  PubMed  PubMed Central  Google Scholar 

  2. 2.

    Severinghaus JW (1979) Simple, accurate equations for human blood O2 dissociation computations. J Appl Physiol Respir Environ Exerc Physiol 46:599–602

    CAS  PubMed  Google Scholar 

  3. 3.

    Collins JA, Rudenski A, Gibson J, Howard L, O’Driscoll R (2015) Relating oxygen partial pressure, saturation and content: the haemoglobin-oxygen dissociation curve. Breathe (Sheff) 11:194–201

    Article  Google Scholar 

  4. 4.

    Kim EH, Lee JH, Song IK, Kim HS, Jang YE, Yoo S, Kim JT (2019) Accuracy of pulse oximeters at low oxygen saturations in children with congenital cyanotic heart disease: an observational study. Paediatr Anaesth 29(6):597–603

    Article  Google Scholar 

  5. 5.

    Griksaitis MJ, Scrimgeour GE, Pappachan JV, Baldock AJ (2016) Accuracy of the Masimo SET(R) LNCS neo peripheral pulse oximeter in cyanotic congenital heart disease. Cardiol Young 26:1183–1186

    Article  Google Scholar 

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Correspondence to Peter C. Laussen.

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Peter Laussen—lead developer T3 software platform, and unpaid medical consultant Etiometry LLC, Boston, Massachusetts. None of the other authors have any conflict of interest.

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Eytan, D., Mazwi, M.L., Goodwin, A.J. et al. Revisiting oxygen dissociation curves and bedside measured arterial saturation in critically ill children. Intensive Care Med 45, 1832–1834 (2019).

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