Intensive Care Medicine

, Volume 45, Issue 4, pp 512–515 | Cite as

What’s new on emerging resistant Candida species

  • Andrea CortegianiEmail author
  • Giovanni Misseri
  • Anuradha Chowdhary
What's New in Intensive Care


Accounting for more than 400,000 annual cases worldwide, with an incidence from 0.24 to 34.3 patients/1000 ICU admissions and mortality that approaches 40%, Candida spp. constitute the third or fourth most common cause of healthcare-related infections worldwide [1]. Although C. albicans remains the main causative pathogen, the increasing isolations of non-albicans Candida spp. resistant to first- and second-line antifungals (namely, fluconazole and echinocandins) in nosocomial infections is concerning. Resistance to azoles remains uncommon in C. albicans (< 5%), but it is more prevalent in C. glabrata (4–16%), C. parapsilosis (4–10%), and C. tropicalis (4–9%) [2]. Acquired resistance following echinocandin exposure appears to be on the rise, and the emergence of multi-resistant species among Candida glabrata and the novel pathogen Candida auris poses a serious threat to critically ill patients.

Echinocandin-resistant Candida glabrata

Variable rates of acquired echinocandin...


Compliance with ethical standards

Conflicts of interest

The authors declare no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature and ESICM 2018

Authors and Affiliations

  1. 1.Department of Biopathology and Medical Biotechnologies (DIBIMED), Section of Anesthesia Analgesia Intensive Care and Emergency, Policlinico Paolo GiacconeUniversity of PalermoPalermoItaly
  2. 2.Department of Medical Mycology, Vallabhbhai Patel Chest InstituteUniversity of DelhiDelhiIndia

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