Boosting the injured brain with supplemental energy fuels

This is a preview of subscription content, log in to check access.

Fig. 1

References

  1. 1.

    Glenn TC, Martin NA, Horning MA, McArthur DL, Hovda DA, Vespa P, Brooks GA (2015) Lactate: brain fuel in human traumatic brain injury: a comparison with normal healthy control subjects. J Neurotrauma 32:820–832

    Article  PubMed  PubMed Central  Google Scholar 

  2. 2.

    Magistretti PJ, Allaman I (2018) Lactate in the brain: from metabolic end-product to signalling molecule. Nat Rev Neurosci 19:235–249

    Article  CAS  PubMed  Google Scholar 

  3. 3.

    Prins ML, Matsumoto JH (2014) The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury. J Lipid Res 55:2450–2457

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Jalloh I, Helmy A, Howe DJ, Shannon RJ, Grice P, Mason A, Gallagher CN, Murphy MP, Pickard JD, Menon DK et al (2018) A comparison of oxidative lactate metabolism in traumatically injured brain and control brain. J Neurotrauma 35:2025–2035

    Article  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Wolahan SM, Mao HC, Real C, Vespa PM, Glenn TC (2018) Lactate supplementation in severe traumatic brain injured adults by primed constant infusion of sodium l-lactate. J Neurosci Res 96:688–695

    Article  CAS  PubMed  Google Scholar 

  6. 6.

    Carteron L, Solari D, Patet C, Quintard H, Miroz JP, Bloch J, Daniel RT, Hirt L, Eckert P, Magistretti PJ et al (2018) Hypertonic lactate to improve cerebral perfusion and glucose availability after acute brain injury. Crit Care Med 46:1649–1655

    Article  CAS  PubMed  Google Scholar 

  7. 7.

    Ichai C, Payen JF, Orban JC, Quintard H, Roth H, Legrand R, Francony G, Leverve XM (2013) Half-molar sodium lactate infusion to prevent intracranial hypertensive episodes in severe traumatic brain injured patients: a randomized controlled trial. Intensive Care Med 39:1413–1422

    Article  CAS  PubMed  Google Scholar 

  8. 8.

    Augustin K, Khabbush A, Williams S, Eaton S, Orford M, Cross JH, Heales SJR, Walker MC, Williams RSB (2018) Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders. Lancet Neurol 17:84–93

    Article  CAS  PubMed  Google Scholar 

  9. 9.

    Stubbs BJ, Cox PJ, Evans RD, Santer P, Miller JJ, Faull OK, Magor-Elliott S, Hiyama S, Stirling M, Clarke K (2017) On the metabolism of exogenous ketones in humans. Front Physiol 8:848

    Article  PubMed  PubMed Central  Google Scholar 

  10. 10.

    Xin L, Ipek Ö, Beaumont M, Shevlyakova M, Christinat N, Masoodi M, Greenberg N, Gruetter R, Cuenoud B (2018) Nutritional ketosis increases NAD+/NAD+ ratio in healthy human brain: an in vivo study by 31P-MRS. Front Nutr 5:62

    Article  PubMed  PubMed Central  Google Scholar 

  11. 11.

    Hashim SA, VanItallie TB (2014) Ketone body therapy: from the ketogenic diet to the oral administration of ketone ester. J Lipid Res 55:1818–1826

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. 12.

    White H, Venkatesh B (2011) Clinical review: ketones and brain injury. Crit Care 15:219

    Article  PubMed  PubMed Central  Google Scholar 

  13. 13.

    Bernini A, Masoodi M, Solari D, Miroz JP, Carteron L, Christinat N, Morelli P, Beaumont M, Abed-Maillard S, Hartweg M et al (2018) Modulation of cerebral ketone metabolism following traumatic brain injury in humans. J Cereb Blood Flow Metab 24:271678X18808947. https://doi.org/10.1177/0271678X18808947

  14. 14.

    Cox PJ, Kirk T, Ashmore T, Willerton K, Evans R, Smith A, Murray AJ, Stubbs B, West J, McLure SW et al (2016) Nutritional ketosis alters fuel preference and thereby endurance performance in athletes. Cell Metab 24:256–268

    Article  CAS  PubMed  Google Scholar 

  15. 15.

    Svart M, Gormsen LC, Hansen J, Zeidler D, Gejl M, Vang K, Aanerud J, Moeller N (2018) Regional cerebral effects of ketone body infusion with 3-hydroxybutyrate in humans: reduced glucose uptake, unchanged oxygen consumption and increased blood flow by positron emission tomography. A randomized, controlled trial. PLoS One 13:e0190556

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

Mauro Oddo is supported by research grants from the Swiss National Science Foundation.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Mauro Oddo.

Ethics declarations

Conflicts of interest

The authors have no conflict of interest to declare.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Oddo, M., Vespa, P. & Menon, D.K. Boosting the injured brain with supplemental energy fuels. Intensive Care Med 45, 872–875 (2019). https://doi.org/10.1007/s00134-018-05517-6

Download citation