Skip to main content
SpringerLink
Log in

What endpoints should not be used for clinical studies of acute kidney injury?

  • What's New in Intensive Care
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Kellum JA, Zarbock A, Nadim MK (2017) What endpoints should be used for clinical studies in acute kidney injury? Intensive Care Med 2:1–3. doi:10.1007/s00134-017-4732-1

    Article  Google Scholar 

  2. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group (2012) KDIGO clinical practice guideline for acute kidney injury. Kidney Int 2:1–138

    Article  Google Scholar 

  3. Waikar SS, Bonventre JV (2009) Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol 20:672–679

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Marenzi G, Marana I, Lauri G, Assanelli E, Grazi M, Campodonico J, Trabattoni D, Fabbiocchi F, Montorsi P, Bartorelli AL (2003) The prevention of radiocontrast-agent-induced nephropathy by hemofiltration. N Engl J Med 349:1333–1340

    Article  CAS  PubMed  Google Scholar 

  5. Kellum JA, Sileanu FE, Murugan R, Lucko N, Shaw AD, Clermont G (2015) Classifying AKI by urine output versus serum creatinine level. J Am Soc Nephrol 26:2231–2238

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Chawla LS, Davison DL, Brasha-Mitchell E, Koyner JL, Arthur JM, Shaw AD, Tumlin JA, Trevino SA, Kimmel PL, Seneff MG (2013) Development and standardization of a furosemide stress test to predict the severity of acute kidney injury. Crit Care 17:R207

    Article  PubMed  PubMed Central  Google Scholar 

  7. Cantarovich F, Rangoonwala B, Lorenz H, Verho M, Esnault V (2004) High-dose furosemide for established ARF: a prospective, randomized, double-blind, placebo-controlled, multicenter trial. Am J Kidney Dis 44:402–409

    Article  CAS  PubMed  Google Scholar 

  8. Liu KD, Vijayan A, Rosner MH, Shi J, Chawla LS, Kellum JA (2016) Clinical adjudication in acute kidney injury studies: findings from the pivotal TIMP-2 × IGFBP7 biomarker study. Nephrol Dial Transplant 31:1641–1646

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Koyner JL, Garg AX, Thiessen-Philbrook H, Coca SG, Cantley LG, Peixoto A, Passik CS, Hong K, Parikh CR, Consortium TA (2014) Adjudication of etiology of acute kidney injury: experience from the TRIBE-AKI multi-center study. BMC Nephrol 15:105

    Article  PubMed  PubMed Central  Google Scholar 

  10. Palevsky PM, Zhang JH, O’Connor TZ, Chertow GM, Crowley ST, Choudhury D, Finkel K, Kellum JA, Paganini E, Schein RM, Smith MW, Swanson KM, Thompson BT, Vijayan A, Watnick S, Star RA, Peduzzi P (2008) Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med 359:7–20

    Article  CAS  PubMed  Google Scholar 

  11. Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lo S, McArthur C, McGuinness S, Myburgh J, Norton R, Scheinkestel C, Su S (2009) Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med 361:1627–1638

    Article  PubMed  Google Scholar 

  12. Doi K, Yuen PS, Eisner C, Hu X, Leelahavanichkul A, Schnermann J, Star RA (2009) Reduced production of creatinine limits its use as marker of kidney injury in sepsis. J Am Soc Nephrol 20:1217–1221

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Macedo E, Bouchard J, Soroko SH, Chertow GM, Himmelfarb J, Ikizler TA, Paganini EP, Mehta RL (2010) Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients. Crit Care 14:R82

    Article  PubMed  PubMed Central  Google Scholar 

  14. Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD (2011) Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med 39:2665–2671

    Article  PubMed  PubMed Central  Google Scholar 

  15. Billings FTT, Shaw AD (2014) Clinical trial endpoints in acute kidney injury. Nephron Clin Pract 127:89–93

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Garg AX, Devereaux PJ, Yusuf S, Cuerden MS, Parikh CR, Coca SG, Walsh M, Novick R, Cook RJ, Jain AR, Pan X, Noiseux N, Vik K, Stolf NA, Ritchie A, Favaloro RR, Parvathaneni S, Whitlock RP, Ou Y, Lawrence M, Lamy A, Investigators C (2014) Kidney function after off-pump or on-pump coronary artery bypass graft surgery: a randomized clinical trial. JAMA 311:2191–2198

    Article  PubMed  Google Scholar 

  17. Chertow GM, Palevsky PM, Greene T (2006) Studying the prevention of acute kidney injury: lessons from an 18th-century mathematician. Clin J Am Soc Nephrol 1:1124–1127

    Article  PubMed  Google Scholar 

  18. https://clinicaltrials.gov/ct2/show/NCT02182440. Accessed April 2, 2017

Download references

Author information

Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, VA Pittsburgh Healthcare System and University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Paul M. Palevsky

  2. Divisions of Nephrology and Critical Care Medicine, Departments of Medicine and Anesthesia, University of California, Box 0532, San Francisco, CA, 94143-0532, USA

    Kathleen D. Liu

Authors
  1. Paul M. Palevsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kathleen D. Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kathleen D. Liu.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Palevsky, P.M., Liu, K.D. What endpoints should not be used for clinical studies of acute kidney injury?. Intensive Care Med 44, 363–365 (2018). https://doi.org/10.1007/s00134-017-4841-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-017-4841-x

Keywords

Search

Navigation