Intensive Care Medicine

, Volume 43, Issue 8, pp 1132–1134 | Cite as

What’s new with stress ulcer prophylaxis in the ICU?

  • Søren Marker
  • Mette Krag
  • Morten Hylander MøllerEmail author
What's New in Intensive Care

What is known?

Critically ill patients are at risk of stress-related mucosal erosions [1]. These are typically superficial and asymptomatic but may progress to ulceration and overt and clinically important gastrointestinal (GI) bleeding, a serious condition associated with increased morbidity and mortality [2]. The reported incidence of GI bleeding varies between 2 and 5% [3, 4], probably because of heterogeneous populations, varying definitions of GI bleeding, and difficulties in diagnosing stress ulcers [3, 4]. Importantly, stress ulcerations have been identified as the sole source of GI bleeding by endoscopy in fewer than 50% of patients with GI bleeding [5]. A number of risk factors for stress ulcer-related bleedings have been suggested, including mechanical ventilation, coagulopathy, acute kidney injury, hepatic failure, and disease severity [2, 3, 4, 6]. A protective effect of enteral nutrition has been proposed [1], however this has not been confirmed in subsequent studies [6].



Intensive Care Unit Intensive Care Unit Patient Clostridium Difficile Infection Lansoprazole Pantoprazole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Compliance with ethical standards

Conflicts of interest

The authors are members of the Steering Committee of the Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP-ICU) trial. The authors declare no other conflicts of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2017

Authors and Affiliations

  • Søren Marker
    • 1
  • Mette Krag
    • 1
  • Morten Hylander Møller
    • 1
    Email author
  1. 1.Department of Intensive Care, 4131, Copenhagen University HospitalRigshospitaletCopenhagenDenmark

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