Skip to main content

Advertisement

Log in

What’s new in skin antisepsis for short-term intravascular catheters: new data to address old problems?

  • What's New in Intensive Care
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Frasca D, Dahyot-Fizelier C, Mimoz O (2010) Prevention of central venous catheter-related infection in the intensive care unit. Crit Care 14:212

    Article  PubMed  PubMed Central  Google Scholar 

  2. Chaiyakunapruk N, Veenstra DL, Lipsky BA, Saint S (2002) Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med 136:792–801

    Article  CAS  PubMed  Google Scholar 

  3. Pages J, Hazera P, Mégarbane B, du Cheyron D, Thuong M, Dutheil JJ, Valette X, Fournel F, Mermel LA, Mira JP, Daubin C, Parienti JJ, 3SITES Study Group (2016) Comparison of alcoholic chlorhexidine and povidone-iodine cutaneous antiseptics for the prevention of central venous catheter-related infection: a cohort and quasi-experimental multicenter study. Intensive Care Med. doi:10.1007/s00134-016-4406-4

  4. Mimoz O, Lucet JC, Kerforne T, Pascal J, Souweine B, Goudet V, Mercat A, Bouadma L, Lasocki S, Alfandari S, Friggeri A, Wallet F, Allou N, Ruckly S, Balayn D, Lepape A, Timsit JF, CLEAN trial investigators (2015) Skin antisepsis with chlorhexidine-alcohol versus povidone iodine-alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial. Lancet 386:2069–2077

    Article  CAS  PubMed  Google Scholar 

  5. Mimoz O, Chopra V, Timsit JF (2016) What’s new in catheter-related infection: skin cleansing and skin antisepsis. Intensive Care Med. doi:10.1007/s00134-016-4244-4

  6. Darouiche RO, Wall MJ Jr, Itani KM, Otterson MF, Webb AL, Carrick MM, Miller HJ, Awad SS, Crosby CT, Mosier MC, Alsharif A, Berger DH (2010) Chlorhexidine-alcohol versus povidone-iodine for surgical-site antisepsis. N Engl J Med 362:18–26

    Article  CAS  PubMed  Google Scholar 

  7. Tuuli MG, Liu J, Stout MJ, Martin S, Cahill AG, Odibo AO, Colditz GA, Macones GA (2016) A randomized trial comparing skin antiseptic agents at cesarean delivery. N Engl J Med 374:647–655

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Casey A, Itrakjy A, Birkett C, Clethro A, Bonser R, Graham T, Mascaro J, Pagano D, Rooney S, Wilson I, Nightingale P, Crosby C, Elliott T (2015) A comparison of the efficacy of 70 % v/v isopropyl alcohol with either 0.5 % w/v or 2 % w/v chlorhexidine gluconate for skin preparation before harvest of the long saphenous vein used in coronary artery bypass grafting. Am J Infect Control 43:816–820

    Article  CAS  PubMed  Google Scholar 

  9. Stewart BJ, Gardiner T, Perry GJ, Tong SY (2016) Reduction in Staphylococcus aureus bacteraemia rates in patients receiving haemodialysis following alteration of skin antisepsis procedures. J Hosp Infect 92:191–193

    Article  CAS  PubMed  Google Scholar 

  10. McCann M, Fitzpatrick F, Mellotte G, Clarke M (2016) Is 2 % chlorhexidine gluconate in 70 % isopropyl alcohol more effective at preventing central venous catheter-related infections than routinely used chlorhexidine gluconate solutions: a pilot multicenter randomized trial (ISRCTN2657745)? Am J Infect Control 44:948–949

  11. Warren DK, Prager M, Munigala S, Wallace MA, Kennedy CR, Bommarito KM, Mazuski JE, Burnham CA (2016) Prevalence of qacA/B genes and mupirocin resistance among methicillin-resistant Staphylococcus aureus (MRSA) isolates in the setting of chlorhexidine bathing without mupirocin. Infect Control Hosp Epidemiol 37:590–597

    Article  PubMed  Google Scholar 

  12. Dettenkofer M, Wilson C, Gratwohl A, Schmoor C, Bertz H, Frei R, Heim D, Luft D, Schulz S, Widmer AF (2010) Skin disinfection with octenidine dihydrochloride for central venous catheter site care: a double-blind, randomized, controlled trial. Clin Microbiol Infect 16:600–606

    Article  CAS  PubMed  Google Scholar 

  13. Tietz A, Frei R, Dangel M, Bolliger D, Passweg JR, Gratwohl A, Widmer AE (2005) Octenidine hydrochloride for the care of central venous catheter insertion sites in severely immunocompromised patients. Infect Control Hosp Epidemiol 26:703–707

    Article  PubMed  Google Scholar 

  14. Bilir A, Yelken B, Erkan A (2013) Chlorhexidine, octenidine or povidone iodine for catheter related infections: a randomized controlled trial. J Res Med Sci 18:510–512

    PubMed  PubMed Central  Google Scholar 

  15. Forni C, Sabattini T, D’Alessandro F, Fiorani A, Gamberini S, Maso A, Curci R, Zanotti E, Chiari P (2015) Use of sodium hypochlorite for skin antisepsis before inserting a peripheral venous catheter: a pilot study. Biol Res Nurs 17:330–333

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Olivier Mimoz.

Ethics declarations

Conflicts of interest

O.M. received research grants, lecture, and consultancy fees from CareFusion. V.C. is supported by a career development award from the Agency for Healthcare Quality Research. A.W. received a grant from the Swiss National Science Foundation # 32003B-149736.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mimoz, O., Chopra, V. & Widmer, A. What’s new in skin antisepsis for short-term intravascular catheters: new data to address old problems?. Intensive Care Med 42, 2043–2045 (2016). https://doi.org/10.1007/s00134-016-4490-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-016-4490-5

Keywords

Navigation