Intensive Care Medicine

, Volume 42, Issue 9, pp 1398–1407 | Cite as

Effect of atorvastatin on the incidence of acute kidney injury following valvular heart surgery: a randomized, placebo-controlled trial

  • Jin Ha Park
  • Jae-Kwang Shim
  • Jong-Wook Song
  • Sarah Soh
  • Young-Lan KwakEmail author



Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors have the potential to reduce acute kidney injury (AKI) after cardiac surgery through their pleiotropic properties. Here we studied the preventive effect of atorvastatin on AKI after valvular heart surgery.


Two-hundred statin-naïve patients were randomly allocated to receive either statin or placebo. Atorvastatin was administered orally to the statin group according to a dosage schedule (80 mg single dose on the evening prior to surgery; 40 mg on the morning of surgery; three further doses of 40 mg on the evenings of postoperative days 0, 1, and 2). AKI incidence was assessed during the first 48 postoperative hours on the basis of Acute Kidney Injury Network criteria.


The incidence of AKI was similar in the statin and control groups (21 vs. 26 %, respectively, p = 0.404). Biomarkers of renal injury including plasma neutrophil gelatinase-associated lipocalin and interleukin-18 were also similar between the groups. The statin group required significantly less norepinephrine and vasopressin during surgery, and fewer patients in the statin group required vasopressin. There were no significant differences in postoperative outcomes.


Acute perioperative statin treatment was not associated with a lower incidence of AKI or improved clinical outcome in patients undergoing valvular heart surgery. ( NCT01909739).


Acute kidney injury Cardiac surgery Cardiopulmonary bypass Statins 



No financial support.

Compliance with ethical standards



Conflicts of interest

The authors declare that they have no conflict of list.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.


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Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2016

Authors and Affiliations

  • Jin Ha Park
    • 1
  • Jae-Kwang Shim
    • 1
    • 2
  • Jong-Wook Song
    • 1
    • 2
  • Sarah Soh
    • 1
  • Young-Lan Kwak
    • 1
    • 2
    Email author
  1. 1.Department of Anesthesiology and Pain MedicineYonsei University College of MedicineSeoulRepublic of Korea
  2. 2.Anesthesia and Pain Research Institute, Yonsei Cardiovascular Research InstituteYonsei University College of MedicineSeoulRepublic of Korea

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