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What’s new in vasopressin?

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References

  1. Serpa Neto A et al (2012) Vasopressin and terlipressin in adult vasodilatory shock: a systematic review and meta-analysis of nine randomized controlled trials. Crit Care 16(4):R154

    Article  PubMed Central  PubMed  Google Scholar 

  2. Polito A et al (2012) Vasopressin for treatment of vasodilatory shock: an ESICM systematic review and meta-analysis. Intensive Care Med 38(1):9–19

    Article  CAS  PubMed  Google Scholar 

  3. Dellinger RP et al (2013) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 39(2):165–228

    Article  CAS  PubMed  Google Scholar 

  4. Russell JA et al (2008) Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 358(9):877–887

    Article  CAS  PubMed  Google Scholar 

  5. Wacharasint P et al (2012) Normal-range blood lactate concentration in septic shock is prognostic and predictive. Shock 38(1):4–10

    Article  CAS  PubMed  Google Scholar 

  6. Gordon AC et al (2012) The cardiopulmonary effects of vasopressin compared with norepinephrine in septic shock. Chest 142(3):593–605

    Article  CAS  PubMed  Google Scholar 

  7. Morelli A et al (2013) Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA 310(16):1683–1691

    Article  PubMed  Google Scholar 

  8. Gordon AC et al (2010) The effects of vasopressin on acute kidney injury in septic shock. Intensive Care Med 36(1):83–91

    Article  CAS  PubMed  Google Scholar 

  9. Russell JA et al (2009) Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock. Crit Care Med 37(3):811–818

    Article  CAS  PubMed  Google Scholar 

  10. Gordon AC et al (2014) The interaction of vasopressin and corticosteroids in septic shock: a pilot randomized controlled trial. Crit Care Med 42(6):1325–1333

    Article  CAS  PubMed  Google Scholar 

  11. Gordon AC et al (2014) Protocol for a randomised controlled trial of VAsopressin versus Noradrenaline as Initial therapy in Septic sHock (VANISH). BMJ Open 4(7):e005866

    Article  PubMed Central  PubMed  Google Scholar 

  12. Baker C et al (2003) Corticotropin-releasing hormone immunoreactivity in human T and B cells and macrophages: colocalization with arginine vasopressin. J Neuroendocrinol 15(11):1070–1074

    Article  CAS  PubMed  Google Scholar 

  13. Russell JA et al (2013) Vasopressin compared with norepinephrine augments the decline of plasma cytokine levels in septic shock. Am J Respir Crit Care Med 188(3):356–364

    Article  CAS  PubMed  Google Scholar 

  14. Anantasit N et al (2014) Serious adverse events associated with vasopressin and norepinephrine infusion in septic shock. Crit Care Med 42(8):1812–1820

    Article  CAS  PubMed  Google Scholar 

  15. Mehta S et al (2013) Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine. Crit Care 17(3):R117

    Article  PubMed Central  PubMed  Google Scholar 

  16. Nakada TA et al (2011) Leucyl/cystinyl aminopeptidase gene variants in septic shock. Chest 139(5):1042–1049

    Article  CAS  PubMed  Google Scholar 

  17. Maybauer MO et al (2014) The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis. Crit Care Med 42(7):e525–e533

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  18. Mentzelopoulos SD et al (2013) Vasopressin, steroids, and epinephrine and neurologically favorable survival after in-hospital cardiac arrest: a randomized clinical trial. JAMA 310(3):270–279

    Article  PubMed  Google Scholar 

  19. Hajjar L, Vincent JL, Rhodes A, Galas F, Fukushima JT, Osawa EA, Grande SM, Almeida JP, Zefferino S, Camara L, Jatene FB, Filho RK (2014) Vasopressin or norepinephrine in vasoplegia after cardiac surgery (VANCS study): a randomised, double-blind and controlled study. Intensive Care Med 40 (Suppl 1):S126

    Google Scholar 

  20. Cossu AP et al (2014) Vasopressin in hemorrhagic shock: a systematic review and meta-analysis of randomized animal trials. Biomed Res Int 2014:421291

    PubMed Central  PubMed  Google Scholar 

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Acknowledgments

Dr. Gordon is funded by a National Institute for Health Research (NIHR) Clinician Scientist Fellowship. The views expressed are those of the author and not necessarily those of the NHS, the NIHR or the Department of Health.

Conflicts of interest

Dr. Gordon has grants from the NIHR and Intensive Care Foundation to investigate vasopressin. He reports receiving non-financial support and speaker fees from Orion Pharmaceuticals, a grant from Tenax Therapeutics and consulting fees from Ferring Pharmaceuticals and Baxter Healthcare.

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Correspondence to Anthony C. Gordon.

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O’Callaghan, D.J.P., Gordon, A.C. What’s new in vasopressin?. Intensive Care Med 41, 2177–2179 (2015). https://doi.org/10.1007/s00134-015-3849-3

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  • DOI: https://doi.org/10.1007/s00134-015-3849-3

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