Ebola care and research protocols
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Thousands of patients have died in West Africa during the worst Ebola virus disease (EVD) epidemic recorded to date, and many more patients will die in the coming months . The overall case fatality rate in West Africa is 60–70 % but this rate is highly variable, depending greatly upon the treatment centre. Mortality also appears to be lower in repatriated patients and in infected healthcare workers receiving intensive care in non-resource constrained settings. Both of these findings suggest that effective supportive care has the potential to increase survival.
EVD is a febrile illness with severe gastrointestinal manifestations starting 3–5 days after symptom onset . Vomiting and diarrhoea cause profound water and electrolyte depletion and ultimately hypovolaemia and shock [3, 4, 5, 6, 7, 8]. High blood levels of creatinine and urea, indicating dehydration, are associated with mortality . Pro-inflammatory mediators may contribute to vascular leakage, hypotension and...
KeywordsPersonal Protective Equipment Oral Rehydration Solution Parenteral Access Balance Crystalloid Electrolyte Management
Conflicts of interest
The ICU at Rigshospitalet, where AP is head of research, receives research funds from Fresenius Kabi and CSL Behring. The other authors have no conflicts of interests.
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