Intensive Care Medicine

, Volume 40, Issue 4, pp 471–483 | Cite as

Year in review in Intensive Care Medicine 2013: III. Sepsis, infections, respiratory diseases, pediatrics

  • Jean-Francois Timsit
  • Giuseppe Citerio
  • Jan Bakker
  • Matteo Bassetti
  • Dominique Benoit
  • Maurizio Cecconi
  • J. Randall Curtis
  • Glenn Hernandez
  • Margaret Herridge
  • Samir Jaber
  • Michael Joannidis
  • Laurent Papazian
  • Mark Peters
  • Pierre Singer
  • Martin Smith
  • Marcio Soares
  • Antoni Torres
  • Antoine Vieillard-Baron
  • Elie AzoulayEmail author
Year in Review 2013

Micro- and macrocirculation in septic shock and severe sepsis

Dobutamine has been widely advocated to improve (inadequate) cardiac output in septic shock. However, on the basis of the double-blind, crossover, randomized study from Hernandez et al. [1], the microcirculatory and regional effects, despite improvement of the macrocirculation, seem to be limited. Indeed despite an increase in cardiac output and heart rate, with dobutamine, they found no significant impact on lactate level and sublingual vessel perfused density. This is in contrast to some other studies. The question now is were the results of these earlier studies wrong or is the current baseline resuscitation of critically ill patients so different from these earlier days that the state of the vasculature of our patients is now different when compared to those earlier days?

A change of case-mix related to these critical endothelial factors such as variations of endothelial protein C receptor polymorphisms [2] or of...


Systemic Inflammatory Response Syndrome Colistin Intensive Care Unit Mortality Noninvasive Positive Pressure Ventilation Selective Digestive Decontamination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflicts of interest



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Copyright information

© Springer-Verlag Berlin Heidelberg and ESICM 2014

Authors and Affiliations

  • Jean-Francois Timsit
    • 1
    • 21
    • 22
  • Giuseppe Citerio
    • 2
  • Jan Bakker
    • 3
  • Matteo Bassetti
    • 4
  • Dominique Benoit
    • 5
  • Maurizio Cecconi
    • 6
  • J. Randall Curtis
    • 7
  • Glenn Hernandez
    • 8
  • Margaret Herridge
    • 9
  • Samir Jaber
    • 10
  • Michael Joannidis
    • 11
  • Laurent Papazian
    • 12
  • Mark Peters
    • 13
  • Pierre Singer
    • 14
  • Martin Smith
    • 15
  • Marcio Soares
    • 16
  • Antoni Torres
    • 17
  • Antoine Vieillard-Baron
    • 18
  • Elie Azoulay
    • 19
    • 20
    Email author
  1. 1.Medical and Infectious Diseases ICU, Bichat HospitalParis Diderot UniversityParisFrance
  2. 2.NeuroIntensive Care Unit, Department of Anaesthesia and Critical CareOspedale San GerardoMonzaItaly
  3. 3.Erasmus University Medical CenterRotterdamThe Netherlands
  4. 4.Azienda Ospedaliera Universitaria Santa Maria della MisericordiaUdineItaly
  5. 5.Ghent University HospitalGhentBelgium
  6. 6.St George’s HospitalLondonUK
  7. 7.Harborview Medical CenterUniversity of WashingtonSeattleUSA
  8. 8.Pontificia Universidad CatólicaSantiago de ChileChile
  9. 9.University of TorontoTorontoCanada
  10. 10.Saint Eloi University HospitalMontpellierFrance
  11. 11.Medical UniversityInnsbruckAustria
  12. 12.Hôpital NordMarseilleFrance
  13. 13.Great Ormond St HospitalLondonUK
  14. 14.Beilinson HospitalTel AvivIsrael
  15. 15.University College London HospitalsLondonUK
  16. 16.D’Or Institute for Research and EducationRio de JaneiroBrazil
  17. 17.Hospital ClinicUniversity of Barcelona, Ciberes, IDIBAPSBarcelonaSpain
  18. 18.Hôpital Ambroise ParéParisFrance
  19. 19.Medical ICU, AP-HPHôpital Saint-LouisParisFrance
  20. 20.Faculté de Medicine, Sorbonne Paris-CitéUniversité Paris-DiderotParisFrance
  21. 21.Sorbonne Paris-CitéUniv Paris DiderotParisFrance
  22. 22.IAME Team 5, DeSCID: Decision SCiences in Infectious Diseases, Control and Care InsermUMR 1137 Paris Diderot UniversityParisFrance

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